OpenClaim

Trimethadione Side Effects

The most commonly reported side effects of trimethadione include foetal exposure during pregnancy, convulsion, and death, based on 47 FDA adverse event reports from 2004 to 2025. 10.6% of reports found the drug to be ineffective.

Trimethadione side effects

Percentages show how often each reaction appears relative to total reports for trimethadione.

1
Foetal Exposure During Pregnancy12.8%6
2
Drug Ineffective10.6%5
3
Convulsion6.4%3
4
Death6.4%3
5
Premature Baby6.4%3
6
Blood Calcium Increased4.3%2
7
Cerebrovascular Accident4.3%2
8
Abdominal Discomfort4.3%2
9
Fatigue4.3%2
10
Dizziness4.3%2
11
Growth Retardation4.3%2
12
Off Label Use4.3%2
13
Pancytopenia4.3%2
14
Aplastic Anaemia4.3%2
15
Toxicity To Various Agents4.3%2

These are voluntary reports and do not establish that trimethadione caused these reactions.

Report severity

76.6%Serious36 reports
19.1%Hospitalizations9 reports
17.0%Fatal8 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trimethadione drug interactions

Other drugs that appear in adverse event reports alongside trimethadione. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Phenytoin23.4%11
2
Phenobarbital-sodium17.0%8
3
Levetiracetam12.8%6
4
Carbamazepine8.5%4
5
Clonazepam8.5%4
6
Tenofovir8.5%4
7
Primidone8.5%4
8
Gabapentin6.4%3
9
Lamotrigine6.4%3
10
Topiramate6.4%3
11
Valproic-acid6.4%3
12
Ethotoin6.4%3
13
Emtricitabine6.4%3
14
Diazepam4.3%2
15
Oxcarbazepine4.3%2

Taken alongside

1
Phenytoin21.3%10
2
Phenobarbital-sodium14.9%7
3
Clonazepam12.8%6
4
Valproic-acid10.6%5
5
Carbamazepine10.6%5
6
Diazepam10.6%5
7
Gabapentin10.6%5
8
Topiramate10.6%5
9
Levothyroxine-sodium8.5%4
10
Oxcarbazepine8.5%4
11
Trazodone-hydrochloride8.5%4
12
Lamotrigine8.5%4
13
Aspirin8.5%4
14
Undecoylium-chloride-iodine-complex8.5%4
15
Isotretinoin8.5%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trimethadione side effects

63.8% of trimethadione adverse event reports involve female patients and 25.5% involve male patients. The largest age group is adult at 44%. These figures reflect who reports side effects, not underlying risk.

Sex

Female63.8%
Male25.5%
Unknown10.6%

Age group

< 212.0%
2–1116.0%
12–174.0%
18–6444.0%
65+24.0%

What is trimethadione used for

Conditions and purposes for which patients were taking trimethadione when the adverse event was reported.

AnxietyCardiac DisorderChronic Obstructive Pulmonary DiseaseContraceptionConvulsionEpilepsyGeneralised Tonic-clonic SeizureLennox-gastaut SyndromeMaternal Exposure Timing UnspecifiedPetit Mal EpilepsyProduct Used For Unknown IndicationProduct Used For Unknown IndicationSeizure

Trimethadione brand names and reporting trend

Trimethadione is sold under the brand name Tridione.

Brand names

Tridione26

Quarterly reports (20042025)

2004201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trimethadione with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.