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Trimeprazine Side Effects

The most commonly reported side effects of trimeprazine include coma, toxicity to various agents, and poisoning deliberate, based on 2,558 FDA adverse event reports from 2004 to 2025.

Trimeprazine side effects

Percentages show how often each reaction appears relative to total reports for trimeprazine.

1
Coma11.2%286
2
Toxicity To Various Agents8.3%213
3
Poisoning Deliberate6.8%173
4
Drug Abuse6.6%170
5
Intentional Overdose6.6%168
6
Somnolence5.1%131
7
Drug Use Disorder4.2%107
8
Intentional Self-injury3.7%95
9
Substance Use Disorder3.7%94
10
Drug Interaction3.4%86
11
Hepatic Cytolysis3.2%83
12
Poisoning3.2%82
13
Death3.0%77
14
Altered State Of Consciousness3.0%76
15
Suicide Attempt2.9%73

These are voluntary reports and do not establish that trimeprazine caused these reactions.

Report severity

99.4%Serious2,542 reports
56.3%Hospitalizations1,441 reports
17.2%Fatal440 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trimeprazine drug interactions

Other drugs that appear in adverse event reports alongside trimeprazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Diazepam17.9%459
2
Quetiapine-fumarate10.5%269
3
Loxapine10.4%266
4
Oxazepam10.4%265
5
Olanzapine10.0%256
6
Cocaine-hydrochloride8.1%207
7
Eszopiclone7.9%203
8
Mirtazapine7.5%193
9
Aripiprazole7.5%192
10
Venlafaxine7.5%191
11
Sertraline-hydrochloride7.3%186
12
Risperidone6.9%176
13
Alprazolam6.8%175
14
Tramadol-hydrochloride6.3%161
15
Paroxetine6.2%159

Taken alongside

1
Acetaminophen7.0%178
2
Eszopiclone5.8%149
3
Diazepam5.2%134
4
Levothyroxine-sodium4.3%110
5
Oxazepam4.0%102
6
Omeprazole3.9%101
7
Loxapine3.4%87
8
Pantoprazole-sodium3.4%86
9
Mirtazapine3.3%84
10
Alprazolam3.2%82
11
Venlafaxine3.2%81
12
Aripiprazole3.0%78
13
Atorvastatin-calcium3.0%76
14
Quetiapine-fumarate2.9%75
15
Furosemide2.9%73

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trimeprazine side effects

49.2% of trimeprazine adverse event reports involve female patients and 42.7% involve male patients. The largest age group is adult at 74%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.2%
Male42.7%
Unknown8.1%

Age group

< 21.0%
2–111.6%
12–176.0%
18–6474.0%
65+17.5%

What is trimeprazine used for

Conditions and purposes for which patients were taking trimeprazine when the adverse event was reported.

Abnormal BehaviourAffective DisorderAgitationAntiallergic TherapyAnxietyAttention Deficit/hyperactivity DisorderAffective DisorderAfrican TrypanosomiasisAgitationAlcoholismAntiallergic TherapyAntipsychotic TherapyAnxietyAnxiety DisorderAnxiolytic Therapy

Showing 15 of 104 indications

Trimeprazine brand names and reporting trend

Trimeprazine is sold under the brand name Trimeprazine Tartrate.

Brand names

Trimeprazine Tartrate3

Quarterly reports (20042025)

2005201020202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trimeprazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.