OpenClaim

Trilostane Side Effects

The most commonly reported side effects of trilostane include nausea, adrenal neoplasm, and granulocytopenia, based on 12 FDA adverse event reports from 2004 to 2024.

Trilostane side effects

Percentages show how often each reaction appears relative to total reports for trilostane.

1
Nausea16.7%2
2
Adrenal Neoplasm8.3%1
3
Granulocytopenia8.3%1
4
Hepatic Function Abnormal8.3%1
5
Renal Impairment8.3%1
6
Bone Disorder8.3%1
7
Dental Caries8.3%1
8
Local Anaesthesia8.3%1
9
Mouth Ulceration8.3%1
10
Osteonecrosis8.3%1
11
Arrhythmia8.3%1
12
Blood Potassium Decreased8.3%1
13
Spinal Compression Fracture8.3%1
14
Gastrointestinal Haemorrhage8.3%1
15
Increased Appetite8.3%1

These are voluntary reports and do not establish that trilostane caused these reactions.

Report severity

58.3%Serious7 reports
33.3%Hospitalizations4 reports
8.3%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trilostane drug interactions

Other drugs that appear in adverse event reports alongside trilostane. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Metyrapone25.0%3
2
Osilodrostat-phosphate16.7%2
3
Pasireotide16.7%2
4
Atenolol8.3%1
5
Carvedilol8.3%1
6
Famotidine8.3%1
7
Potassium-chloride8.3%1
8
Zoledronic-acid8.3%1
9
Insulin8.3%1
10
Dabigatran-etexilate-mesylate8.3%1
11
Cannabidiol8.3%1
12
Adapalene8.3%1
13
Lenalidomide8.3%1
14
Dupilumab8.3%1

Taken alongside

1
Hydrocortisone16.7%2
2
Potassium-phosphate-monobasic16.7%2
3
Metformin16.7%2
4
Azelastine16.7%2
5
Fluconazole8.3%1
6
Latanoprost8.3%1
7
Nifedipine8.3%1
8
Leuprolide8.3%1
9
Warfarin8.3%1
10
Ketoconazole8.3%1
11
Dronedarone8.3%1
12
Nebivolol-hydrochloride8.3%1
13
Losartan-potassium8.3%1
14
Fluticasone8.3%1
15
Salmeterol-xinafoate8.3%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trilostane side effects

33.3% of trilostane adverse event reports involve female patients and 25.0% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.3%
Male25.0%
Unknown41.7%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6457.1%
65+42.9%

What is trilostane used for

Conditions and purposes for which patients were taking trilostane when the adverse event was reported.

Cushing's SyndromeEctopic Acth SyndromeMalignant Mediastinal NeoplasmProduct Used For Unknown IndicationProstate CancerPituitary-dependent Cushing^s Syndrome

Trilostane brand names and reporting trend

Trilostane is sold under the brand name Modrastane.

Brand names

Modrastane14

Quarterly reports (20042024)

20042024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trilostane with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.