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Trilaciclib Side Effects

The most commonly reported side effects of trilaciclib include myelosuppression, anaemia, and pyrexia, based on 395 FDA adverse event reports from 2004 to 2025.

Trilaciclib side effects

Percentages show how often each reaction appears relative to total reports for trilaciclib.

1
Myelosuppression8.9%35
2
Anaemia8.6%34
3
Pyrexia8.1%32
4
Off Label Use7.8%31
5
Nausea6.3%25
6
Pneumonia5.8%23
7
Dyspnoea5.8%23
8
Fatigue5.6%22
9
Platelet Count Decreased5.6%22
10
White Blood Cell Count Decreased5.1%20
11
Infection4.3%17
12
Pain4.1%16
13
Death4.1%16
14
Thrombocytopenia3.8%15
15
Sepsis3.8%15

These are voluntary reports and do not establish that trilaciclib caused these reactions.

Report severity

73.9%Serious292 reports
48.4%Hospitalizations191 reports
11.9%Fatal47 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trilaciclib drug interactions

Other drugs that appear in adverse event reports alongside trilaciclib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dexamethasone13.9%55
2
Lenalidomide11.1%44
3
Carboplatin9.1%36
4
Irinotecan-hydrochloride7.6%30
5
Bevacizumab7.3%29
6
Carfilzomib7.1%28
7
Oxaliplatin5.6%22
8
Etoposide4.6%18
9
Fluorouracil4.6%18
10
Cisplatin4.6%18
11
Gemcitabine4.3%17
12
Doxorubicin-hydrochloride4.1%16
13
Levoleucovorin4.1%16
14
Atezolizumab3.8%15
15
Rituximab3.3%13

Taken alongside

1
Sulfamethoxazole13.4%53
2
Trimethoprim12.9%51
3
Pantoprazole-sodium8.4%33
4
Dexamethasone7.6%30
5
Ondansetron7.3%29
6
Etoposide7.3%29
7
Acetaminophen6.8%27
8
Carboplatin6.1%24
9
Ramipril5.3%21
10
Sodium-chloride5.3%21
11
Amlodipine4.6%18
12
Aspirin4.3%17
13
Bisoprolol-fumarate4.3%17
14
Allopurinol4.1%16
15
Prednisone4.1%16

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trilaciclib side effects

30.9% of trilaciclib adverse event reports involve female patients and 33.2% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female30.9%
Male33.2%
Unknown35.9%

Age group

< 20.0%
2–110.4%
12–170.4%
18–6450.9%
65+48.2%

What is trilaciclib used for

Conditions and purposes for which patients were taking trilaciclib when the adverse event was reported.

Abdominal Pain LowerAdverse EventAntibiotic ProphylaxisAntiviral ProphylaxisAdenosquamous Cell Lung Cancer Stage IvBone Marrow Conditioning RegimenBone Marrow DisorderBreast CancerBreast Cancer MetastaticCystic FibrosisCervix CarcinomaChemotherapy Side Effect ProphylaxisColorectal CancerDiarrhoeaEpstein-barr Viraemia

Showing 15 of 51 indications

Trilaciclib brand names and reporting trend

Trilaciclib is sold under the brand name Cosela.

Brand names

Cosela339

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trilaciclib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.