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Trifluoperazine Side Effects

The most commonly reported side effects of trifluoperazine include weight increased, toxicity to various agents, and suicide attempt, based on 2,015 FDA adverse event reports from 2004 to 2025. 15.7% of reports found the drug to be ineffective.

Trifluoperazine side effects

Percentages show how often each reaction appears relative to total reports for trifluoperazine.

1
Drug Ineffective15.7%316
2
Weight Increased10.2%206
3
Toxicity To Various Agents9.9%199
4
Suicide Attempt9.2%186
5
Akathisia8.6%174
6
Increased Appetite8.4%170
7
Obsessive-compulsive Disorder8.1%164
8
Euphoric Mood8.0%162
9
Antipsychotic Drug Level Below Therapeutic7.5%151
10
Disinhibition7.5%151
11
Leukopenia7.4%150
12
Therapeutic Product Effect Incomplete7.3%148
13
Diabetes Mellitus7.2%146
14
Therapeutic Product Effect Variable7.0%142
15
Type 2 Diabetes Mellitus5.9%119

These are voluntary reports and do not establish that trifluoperazine caused these reactions.

Report severity

85.8%Serious1,729 reports
45.6%Hospitalizations919 reports
9.0%Fatal182 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trifluoperazine drug interactions

Other drugs that appear in adverse event reports alongside trifluoperazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate27.2%549
2
Olanzapine23.1%465
3
Risperidone21.5%434
4
Clozapine17.2%347
5
Aripiprazole17.0%343
6
Haloperidol14.5%293
7
Fluoxetine-hydrochloride11.2%225
8
Lithium11.1%223
9
Amisulpride10.5%212
10
Loxapine9.4%190
11
Clomipramine-hydrochloride9.0%181
12
Gabapentin8.7%176
13
Perphenazine8.7%175
14
Ziprasidone8.6%173
15
Thioridazine8.4%170

Taken alongside

1
Risperidone10.6%214
2
Haloperidol10.4%210
3
Aripiprazole9.2%186
4
Olanzapine8.6%174
5
Levothyroxine-sodium7.3%147
6
Ziprasidone7.1%144
7
Lorazepam7.0%142
8
Valproate-sodium6.8%137
9
Chlorpromazine6.6%132
10
Aspirin6.2%125
11
Acetaminophen6.0%121
12
Clonazepam5.8%117
13
Diazepam5.6%113
14
Fluoxetine-hydrochloride5.6%112
15
Citalopram-hydrobromide5.5%110

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trifluoperazine side effects

50.9% of trifluoperazine adverse event reports involve female patients and 42.4% involve male patients. The largest age group is adult at 74%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.9%
Male42.4%
Unknown6.7%

Age group

< 21.8%
2–110.4%
12–172.1%
18–6474.2%
65+21.5%

What is trifluoperazine used for

Conditions and purposes for which patients were taking trifluoperazine when the adverse event was reported.

Abnormal BehaviourAccidental Exposure To ProductAcute PsychosisAdjustment Disorder With Depressed MoodAdolescenceAffective DisorderAggressionAgitationAngerAntidepressant TherapyAnxietyAnxiety DisorderAnxiolytic TherapyAttention Deficit/hyperactivity DisorderAutism Spectrum Disorder

Showing 15 of 108 indications

Trifluoperazine brand names and reporting trend

Trifluoperazine is sold under the brand name Stelazine.

Brand names

Stelazine450

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trifluoperazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.