The most commonly reported side effects of trifarotene include erythema, skin burning sensation, and acne, based on 171 FDA adverse event reports from 2020 to 2025. 5.8% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for trifarotene.
These are voluntary reports and do not establish that trifarotene caused these reactions.
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Other drugs that appear in adverse event reports alongside trifarotene. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
44.4% of trifarotene adverse event reports involve female patients and 5.8% involve male patients. The largest age group is adult at 79%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking trifarotene when the adverse event was reported.
Trifarotene is sold under the brand name Aklief.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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