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Trientine Side Effects

The most commonly reported side effects of trientine include off label use, product dose omission issue, and treatment noncompliance, based on 556 FDA adverse event reports from 2004 to 2025. 3.2% of reports found the drug to be ineffective.

Trientine side effects

Percentages show how often each reaction appears relative to total reports for trientine.

1
Off Label Use13.1%73
2
Product Dose Omission Issue12.6%70
3
Treatment Noncompliance6.1%34
4
Nausea5.6%31
5
Vomiting4.1%23
6
Fatigue4.0%22
7
Abdominal Pain3.8%21
8
Drug Dose Omission3.6%20
9
Death3.4%19
10
Gait Disturbance3.4%19
11
Dystonia3.4%19
12
Diarrhoea3.2%18
13
Drug Ineffective3.2%18
14
Product Storage Error3.1%17
15
Tremor3.1%17

These are voluntary reports and do not establish that trientine caused these reactions.

Report severity

46.6%Serious259 reports
21.9%Hospitalizations122 reports
7.0%Fatal39 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trientine drug interactions

Other drugs that appear in adverse event reports alongside trientine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Zinc-acetate2.5%14
2
Olanzapine2.0%11
3
Penicillamine2.0%11
4
Haloperidol1.8%10
5
Quetiapine-fumarate1.6%9
6
Lansoprazole1.6%9
7
Etanercept1.6%9
8
Zinc-sulfate-heptahydrate-cupric-sulfate-manganese-sulfate-selenious-acid1.4%8
9
Sertraline-hydrochloride1.3%7
10
Venlafaxine1.1%6
11
Zoledronic-acid0.9%5
12
Clonazepam0.7%4
13
Carboplatin0.7%4
14
Prednisone0.7%4
15
Rifaximin0.7%4

Taken alongside

1
Ergocalciferol11.7%65
2
Zinc-sulfate-heptahydrate-cupric-sulfate-manganese-sulfate-selenious-acid10.3%57
3
Acetaminophen5.8%32
4
Atorvastatin-calcium5.0%28
5
Metoprolol4.7%26
6
Zinc-acetate4.1%23
7
Aspirin4.0%22
8
Omeprazole3.6%20
9
Levothyroxine-sodium2.9%16
10
Spironolactone2.7%15
11
Propranolol-hydrochloride2.7%15
12
Albuterol2.7%15
13
Clonazepam2.3%13
14
Pantoprazole-sodium2.3%13
15
Fluticasone2.2%12

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trientine side effects

39.7% of trientine adverse event reports involve female patients and 35.6% involve male patients. The largest age group is adult at 74%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.7%
Male35.6%
Unknown24.6%

Age group

< 20.0%
2–114.1%
12–177.4%
18–6474.4%
65+14.0%

What is trientine used for

Conditions and purposes for which patients were taking trientine when the adverse event was reported.

Angina PectorisBladder CancerChelation TherapyCopper Metabolism DisorderChelation TherapyDrug Use For Unknown IndicationHepatic CirrhosisHepato-lenticular DegenerationHypertensionHepato-lenticular DegenerationHyperthermiaHypertrophic CardiomyopathyImmune System DisorderMetabolic DisorderMineral Metabolism Disorder

Showing 15 of 23 indications

Trientine brand names and reporting trend

Trientine is sold under the brand name Cuvrior.

Brand names

Cuvrior60

Quarterly reports (20042025)

2004201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trientine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.