OpenClaim

Trichlormethiazide Side Effects

The most commonly reported side effects of trichlormethiazide include pneumonia, dyspnoea, and cough, based on 1,798 FDA adverse event reports from 2004 to 2025. 6.6% of reports found the drug to be ineffective.

Trichlormethiazide side effects

Percentages show how often each reaction appears relative to total reports for trichlormethiazide.

1
Pneumonia8.8%159
2
Dyspnoea8.2%147
3
Cough6.6%119
4
Drug Ineffective6.6%119
5
Obstructive Airways Disorder6.0%107
6
Renal Impairment5.8%104
7
Respiratory Tract Infection5.6%100
8
Pulmonary Mass5.6%100
9
Upper-airway Cough Syndrome5.5%98
10
Multiple Allergies5.4%97
11
Sputum Culture Positive5.4%97
12
Bronchial Secretion Retention5.4%97
13
Eosinophil Count Increased5.3%96
14
Vital Capacity Decreased5.3%96
15
Reversible Airways Obstruction5.3%95

These are voluntary reports and do not establish that trichlormethiazide caused these reactions.

Report severity

96.5%Serious1,735 reports
61.4%Hospitalizations1,104 reports
17.6%Fatal317 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trichlormethiazide drug interactions

Other drugs that appear in adverse event reports alongside trichlormethiazide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Furosemide10.3%185
2
Valsartan7.2%130
3
Spironolactone7.2%129
4
Prednisone6.6%119
5
Rosuvastatin6.1%110
6
Tiotropium-bromide5.8%105
7
Budesonide5.7%103
8
Bisoprolol-fumarate5.7%103
9
Levothyroxine-sodium5.7%103
10
Acetaminophen5.6%101
11
Mepolizumab5.6%101
12
Albuterol5.6%100
13
Omalizumab5.5%98
14
Montelukast-sodium5.5%98
15
Diazepam5.4%97

Taken alongside

1
Furosemide25.6%461
2
Amlodipine21.6%389
3
Spironolactone17.4%312
4
Aspirin14.6%262
5
Lansoprazole12.5%224
6
Nifedipine11.2%201
7
Febuxostat9.9%178
8
Tolvaptan9.3%168
9
Carvedilol9.2%165
10
Bisoprolol-fumarate8.9%160
11
Warfarin8.3%150
12
Magnesium-oxide8.0%144
13
Atorvastatin-calcium7.9%142
14
Rosuvastatin7.9%142
15
Valsartan7.5%135

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trichlormethiazide side effects

47.3% of trichlormethiazide adverse event reports involve female patients and 46.4% involve male patients. The largest age group is elderly at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.3%
Male46.4%
Unknown6.3%

Age group

< 20.9%
2–110.9%
12–170.4%
18–6426.5%
65+71.3%

What is trichlormethiazide used for

Conditions and purposes for which patients were taking trichlormethiazide when the adverse event was reported.

Adverse EventAngina PectorisAscitesAscitesBlood Cholesterol IncreasedBlood Pressure AbnormalBlood Pressure ManagementBlood Pressure MeasurementBlood Pressure AbnormalBlood Pressure IncreasedBlood Pressure ManagementBrain Natriuretic Peptide IncreasedCalculus UrinaryCardiac AmyloidosisCardiac Disorder

Showing 15 of 108 indications

Trichlormethiazide brand names and reporting trend

Trichlormethiazide is sold under the brand name Metatensin #4.

Brand names

Metatensin #41,943

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trichlormethiazide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.