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Triamterene Side Effects

The most commonly reported side effects of triamterene include fatigue, nausea, and diarrhoea, based on 25,260 FDA adverse event reports from 2004 to 2025. 3.8% of reports found the drug to be ineffective.

Triamterene side effects

Percentages show how often each reaction appears relative to total reports for triamterene.

1
Fatigue4.3%1,079
2
Drug Ineffective3.8%972
3
Nausea3.8%952
4
Diarrhoea3.7%922
5
Pain3.4%863
6
Nausea3.3%822
7
Chronic Kidney Disease3.0%764
8
Headache2.8%698
9
Dyspnoea2.7%686
10
Dizziness2.7%686
11
Dizziness2.5%639
12
Arthralgia2.4%603
13
Off Label Use2.4%603
14
Dyspnoea2.4%599
15
Pain2.3%590

These are voluntary reports and do not establish that triamterene caused these reactions.

Report severity

57.4%Serious14,493 reports
27.4%Hospitalizations6,910 reports
5.5%Fatal1,383 reports

Seriousness is determined by the reporter, not by OpenClaim.

Triamterene drug interactions

Other drugs that appear in adverse event reports alongside triamterene. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Hydrochlorothiazide6.2%1,567
2
Adalimumab5.8%1,470
3
Lenalidomide4.2%1,052
4
Omeprazole3.2%796
5
Esomeprazole3.1%780
6
Sodium-oxybate2.5%638
7
Pantoprazole-sodium2.1%535
8
Etanercept2.1%524
9
Pregabalin2.0%500
10
Lansoprazole1.9%492
11
Fluticasone1.5%381
12
Rosiglitazone-maleate1.4%354
13
Amlodipine1.3%325
14
Atorvastatin-calcium1.2%311
15
Rofecoxib1.2%307

Taken alongside

1
Hydrochlorothiazide62.5%15,783
2
Aspirin20.5%5,186
3
Levothyroxine-sodium18.6%4,707
4
Acetaminophen17.8%4,498
5
Ergocalciferol15.2%3,849
6
Metoprolol13.6%3,435
7
Amlodipine13.4%3,379
8
Atorvastatin-calcium12.6%3,187
9
Omeprazole12.6%3,179
10
Lisinopril10.8%2,736
11
Albuterol10.5%2,651
12
Simvastatin10.3%2,606
13
Metformin10.2%2,576
14
Gabapentin10.0%2,529
15
Fluticasone9.0%2,281

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports triamterene side effects

72.7% of triamterene adverse event reports involve female patients and 23.2% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female72.7%
Male23.2%
Unknown4.0%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6447.7%
65+52.0%

What is triamterene used for

Conditions and purposes for which patients were taking triamterene when the adverse event was reported.

Abdominal DistensionAnticoagulant TherapyAnxietyAortic Valve IncompetenceAortic Valve ReplacementArrhythmiaArterial Occlusive DiseaseArteriosclerosisArthralgiaArthritisAscitesAsthmaAtrial FibrillationAtrioventricular BlockBalance Disorder

Showing 15 of 252 indications

Triamterene brand names and reporting trend

Triamterene is sold under the brand name Dyazide.

Brand names

Dyazide9,453

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking triamterene with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.