OpenClaim

Treprostinil Side Effects

The most commonly reported side effects of treprostinil include dyspnoea, headache, and diarrhoea, based on 122,738 FDA adverse event reports from 2004 to 2025.

Treprostinil side effects

Percentages show how often each reaction appears relative to total reports for treprostinil.

1
Dyspnoea16.7%20,457
2
Headache13.5%16,606
3
Diarrhoea10.9%13,386
4
Nausea9.8%12,068
5
Cough8.7%10,695
6
Dizziness7.4%9,038
7
Fatigue7.3%8,970
8
Death5.9%7,265
9
Vomiting5.0%6,167
10
Infusion Site Pain4.5%5,571
11
Hypotension4.5%5,506
12
Malaise4.5%5,485
13
Pneumonia4.4%5,362
14
Fluid Retention4.1%4,990
15
Pain In Extremity3.9%4,833

These are voluntary reports and do not establish that treprostinil caused these reactions.

Report severity

58.5%Serious71,762 reports
41.9%Hospitalizations51,422 reports
12.6%Fatal15,429 reports

Seriousness is determined by the reporter, not by OpenClaim.

Treprostinil drug interactions

Other drugs that appear in adverse event reports alongside treprostinil. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ambrisentan16.0%19,638
2
Macitentan6.0%7,305
3
Tadalafil4.4%5,393
4
Bosentan3.5%4,241
5
Riociguat3.4%4,180
6
Sildenafil-citrate2.3%2,800
7
Selexipag1.8%2,231
8
Sotatercept-csrk1.7%2,107
9
Epoprostenol-sodium1.1%1,298
10
Warfarin0.9%1,073
11
Nintedanib0.8%1,039
12
Acetaminophen0.8%922
13
Apixaban0.5%635
14
Furosemide0.5%625
15
Loperamide-hydrochloride0.4%467

Taken alongside

1
Sildenafil-citrate21.8%26,761
2
Tadalafil21.1%25,858
3
Macitentan12.5%15,402
4
Ambrisentan12.0%14,689
5
Oxygen11.8%14,472
6
Warfarin11.6%14,282
7
Furosemide10.2%12,507
8
Acetaminophen6.8%8,296
9
Spironolactone6.4%7,901
10
Apixaban6.2%7,645
11
Albuterol6.1%7,547
12
Aspirin6.1%7,492
13
Ergocalciferol6.1%7,443
14
Riociguat6.0%7,403
15
Potassium-chloride5.4%6,610

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports treprostinil side effects

72.1% of treprostinil adverse event reports involve female patients and 25.2% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female72.1%
Male25.2%
Unknown2.7%

Age group

< 20.9%
2–112.3%
12–171.5%
18–6456.6%
65+38.8%

What is treprostinil used for

Conditions and purposes for which patients were taking treprostinil when the adverse event was reported.

Abortion MissedAccidental Exposure To ProductAcquired Diaphragmatic EventrationAcute Respiratory Distress SyndromeAlveolitis AllergicAnaemiaAntiphospholipid SyndromeAntisynthetase SyndromeAortic StenosisAortic Valve DiseaseArterial RuptureAscitesAssociated With Pulmonary Arterial HypertensionAsthmaAtrial Septal Defect

Showing 15 of 327 indications

Treprostinil brand names and reporting trend

Treprostinil is sold under brand names including Treprostinil, Yutrepia, Orenitram.

Brand names

Treprostinil16,304
Yutrepia4,452
Orenitram284

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking treprostinil with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.