The most commonly reported side effects of trazodone include fatigue, nausea, and off label use, based on 121,193 FDA adverse event reports from 2004 to 2025. 6.6% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for trazodone.
These are voluntary reports and do not establish that trazodone caused these reactions.
Report severity
Seriousness is determined by the reporter, not by OpenClaim.
Other drugs that appear in adverse event reports alongside trazodone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
61.8% of trazodone adverse event reports involve female patients and 31.4% involve male patients. The largest age group is adult at 66%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking trazodone when the adverse event was reported.
Showing 15 of 785 indications
Trazodone is sold under the brand name Desyrel.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.