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Trastuzumab Side Effects

The most commonly reported side effects of trastuzumab include diarrhoea, nausea, and off label use, based on 85,357 FDA adverse event reports from 2004 to 2025.

Trastuzumab side effects

Percentages show how often each reaction appears relative to total reports for trastuzumab.

1
Diarrhoea8.1%6,911
2
Nausea6.7%5,726
3
Off Label Use6.4%5,443
4
Alopecia6.2%5,319
5
Fatigue6.1%5,227
6
Death6.0%5,100
7
Disease Progression5.2%4,421
8
Myelosuppression4.1%3,459
9
Vomiting4.0%3,429
10
Dyspnoea3.6%3,065
11
Pyrexia3.2%2,708
12
Asthenia3.1%2,685
13
Neutropenia2.7%2,323
14
Neuropathy Peripheral2.7%2,320
15
Pain2.6%2,215

These are voluntary reports and do not establish that trastuzumab caused these reactions.

Report severity

82.9%Serious70,797 reports
28.6%Hospitalizations24,388 reports
13.7%Fatal11,696 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trastuzumab drug interactions

Other drugs that appear in adverse event reports alongside trastuzumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pertuzumab24.7%21,086
2
Docetaxel22.1%18,848
3
Paclitaxel12.1%10,289
4
Capecitabine9.8%8,337
5
Carboplatin6.9%5,921
6
Cyclophosphamide5.0%4,232
7
Lapatinib-ditosylate3.8%3,224
8
Tucatinib3.5%2,987
9
Doxorubicin-hydrochloride3.1%2,680
10
Epirubicin-hydrochloride3.1%2,634
11
Fluorouracil2.9%2,485
12
Letrozole2.7%2,334
13
Vinorelbine-tartrate2.5%2,128
14
Oxaliplatin1.9%1,625
15
Bevacizumab1.7%1,464

Taken alongside

1
Dexamethasone7.2%6,180
2
Carboplatin5.8%4,925
3
Docetaxel5.7%4,826
4
Acetaminophen5.1%4,324
5
Paclitaxel4.6%3,912
6
Ondansetron4.4%3,732
7
Pertuzumab3.3%2,842
8
Omeprazole2.9%2,491
9
Cyclophosphamide2.8%2,429
10
Levothyroxine-sodium2.6%2,181
11
Loperamide-hydrochloride2.5%2,106
12
Pantoprazole-sodium2.3%1,952
13
Sodium-chloride2.2%1,913
14
Metoclopramide-hydrochloride2.0%1,730
15
Zoledronic-acid2.0%1,701

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trastuzumab side effects

79.2% of trastuzumab adverse event reports involve female patients and 6.2% involve male patients. The largest age group is adult at 72%. These figures reflect who reports side effects, not underlying risk.

Sex

Female79.2%
Male6.2%
Unknown14.6%

Age group

< 20.2%
2–11<0.1%
12–17<0.1%
18–6471.9%
65+27.9%

What is trastuzumab used for

Conditions and purposes for which patients were taking trastuzumab when the adverse event was reported.

Abdominal PainAbscess LimbAcute Kidney InjuryAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAddison^s DiseaseAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma MetastaticAdenocarcinoma Of ColonAdenocarcinoma Of Salivary GlandAdenocarcinoma Of The CervixAdenocarcinoma PancreasAdenosquamous Carcinoma Of The CervixAdjuvant Therapy

Showing 15 of 901 indications

Trastuzumab brand names and reporting trend

Trastuzumab is sold under several brand names including Herceptin, Kadcyla, Enhertu.

Brand names

Herceptin57,807
Kadcyla3,477
Enhertu930
Ogivri76
Ontruzant21
Trazimera9
Kanjinti4
Hercessi2

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trastuzumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.