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Tranylcypromine Side Effects

The most commonly reported side effects of tranylcypromine include drug interaction, contraindicated product administered, and depression, based on 1,129 FDA adverse event reports from 2004 to 2025. 5.5% of reports found the drug to be ineffective.

Tranylcypromine side effects

Percentages show how often each reaction appears relative to total reports for tranylcypromine.

1
Drug Interaction9.2%104
2
Contraindicated Product Administered7.3%82
3
Depression7.1%80
4
Hypertensive Crisis6.8%77
5
Drug Ineffective5.5%62
6
Drug Ineffective5.4%61
7
Headache5.0%56
8
Hypertension4.9%55
9
Insomnia4.9%55
10
Nausea4.7%53
11
Off Label Use4.3%49
12
Suicidal Ideation4.2%47
13
Fatigue4.0%45
14
Potentiating Drug Interaction3.9%44
15
Drug Interaction3.8%43

These are voluntary reports and do not establish that tranylcypromine caused these reactions.

Report severity

72.0%Serious813 reports
29.8%Hospitalizations336 reports
8.1%Fatal91 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tranylcypromine drug interactions

Other drugs that appear in adverse event reports alongside tranylcypromine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate7.5%85
2
Aripiprazole7.0%79
3
Olanzapine6.3%71
4
Lithium6.1%69
5
Diazepam5.1%58
6
Lamotrigine4.7%53
7
Alprazolam4.6%52
8
Bupropion4.0%45
9
Mirtazapine4.0%45
10
Venlafaxine3.6%41
11
Sertraline-hydrochloride3.6%41
12
Fluoxetine-hydrochloride3.2%36
13
Brexpiprazole2.7%31
14
Risperidone2.7%30
15
Nortriptyline-hydrochloride2.6%29

Taken alongside

1
Levothyroxine-sodium10.2%115
2
Clonazepam8.1%91
3
Lithium6.8%77
4
Alprazolam6.3%71
5
Quetiapine-fumarate6.2%70
6
Omeprazole5.4%61
7
Lorazepam5.3%60
8
Lamotrigine4.7%53
9
Gabapentin4.3%49
10
Acetaminophen4.2%47
11
Pantoprazole-sodium3.9%44
12
Aspirin3.8%43
13
Atorvastatin-calcium3.5%39
14
Eszopiclone3.4%38
15
Diazepam3.3%37

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tranylcypromine side effects

57.0% of tranylcypromine adverse event reports involve female patients and 30.7% involve male patients. The largest age group is adult at 69%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.0%
Male30.7%
Unknown12.3%

Age group

< 20.8%
2–110.4%
12–170.5%
18–6469.3%
65+29.0%

What is tranylcypromine used for

Conditions and purposes for which patients were taking tranylcypromine when the adverse event was reported.

Acute Myeloid LeukaemiaAdrenergic SyndromeAffective DisorderAntidepressant TherapyAnxietyAnxiety DisorderAgitated DepressionAnhedoniaAntidepressant TherapyAnxietyBipolar DisorderBipolar I DisorderBipolar Ii DisorderBipolar Ii DisorderBipolar Disorder

Showing 15 of 61 indications

Tranylcypromine brand names and reporting trend

Tranylcypromine is sold under the brand name Parnate.

Brand names

Parnate945

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tranylcypromine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.