The most commonly reported side effects of trametinib include pyrexia, death, and malignant neoplasm progression, based on 23,632 FDA adverse event reports from 2006 to 2025. 2.7% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for trametinib.
These are voluntary reports and do not establish that trametinib caused these reactions.
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Other drugs that appear in adverse event reports alongside trametinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
43.7% of trametinib adverse event reports involve female patients and 45.7% involve male patients. The largest age group is adult at 55%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking trametinib when the adverse event was reported.
Showing 15 of 879 indications
Trametinib is sold under brand names including Mekinist, Trametinib Dimethyl Sulfoxide.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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