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Trabectedin Side Effects

The most commonly reported side effects of trabectedin include neutropenia, anaemia, and thrombocytopenia, based on 2,228 FDA adverse event reports from 2005 to 2025. 4.0% of reports found the drug to be ineffective.

Trabectedin side effects

Percentages show how often each reaction appears relative to total reports for trabectedin.

1
Neutropenia10.3%229
2
Anaemia9.2%206
3
Thrombocytopenia8.5%190
4
Nausea8.1%181
5
Febrile Neutropenia7.0%156
6
Pancytopenia6.2%139
7
Vomiting6.2%138
8
Off Label Use5.5%122
9
Rhabdomyolysis5.4%121
10
Disease Progression5.4%120
11
Alanine Aminotransferase Increased4.9%110
12
Asthenia4.6%102
13
Pyrexia4.4%98
14
Acute Kidney Injury4.4%98
15
Aspartate Aminotransferase Increased4.4%97

These are voluntary reports and do not establish that trabectedin caused these reactions.

Report severity

91.6%Serious2,041 reports
45.8%Hospitalizations1,021 reports
19.6%Fatal436 reports

Seriousness is determined by the reporter, not by OpenClaim.

Trabectedin drug interactions

Other drugs that appear in adverse event reports alongside trabectedin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Doxorubicin-hydrochloride25.1%560
2
Gemcitabine8.7%193
3
Carboplatin5.6%125
4
Pazopanib-hydrochloride4.6%102
5
Docetaxel4.2%94
6
Paclitaxel4.0%90
7
Ifosfamide4.0%90
8
Irinotecan-hydrochloride3.6%80
9
Bevacizumab3.0%67
10
Olaparib2.6%57
11
Nivolumab2.4%53
12
Temozolomide2.0%45
13
Cisplatin1.9%43
14
Etoposide1.8%40
15
Topotecan-hydrochloride1.8%40

Taken alongside

1
Dexamethasone15.3%341
2
Ondansetron6.1%135
3
Acetaminophen4.2%93
4
Omeprazole3.8%84
5
Levothyroxine-sodium3.1%69
6
Pegfilgrastim3.0%67
7
Doxorubicin-hydrochloride2.5%56
8
Pantoprazole-sodium2.4%54
9
Granisetron2.3%51
10
Aspirin2.2%49
11
Ramipril1.9%43
12
Bisoprolol-fumarate1.9%43
13
Metoclopramide-hydrochloride1.8%41
14
Oxycodone1.7%38
15
Gemcitabine1.7%37

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports trabectedin side effects

59.7% of trabectedin adverse event reports involve female patients and 28.9% involve male patients. The largest age group is adult at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female59.7%
Male28.9%
Unknown11.4%

Age group

< 20.2%
2–111.1%
12–171.2%
18–6464.1%
65+33.4%

What is trabectedin used for

Conditions and purposes for which patients were taking trabectedin when the adverse event was reported.

Abdominal NeoplasmAccidental Exposure To ProductAdenocarcinomaAlveolar RhabdomyosarcomaAlveolar Soft Part SarcomaAngiosarcomaAngiosarcoma MetastaticAbdominal NeoplasmAdverse Drug ReactionAlveolar RhabdomyosarcomaAngiosarcomaBenign Lung NeoplasmBone SarcomaBrca1 Gene MutationBreast Cancer Metastatic

Showing 15 of 207 indications

Trabectedin brand names and reporting trend

Trabectedin is sold under the brand name Trabectedin.

Brand names

Trabectedin1,735

Quarterly reports (20052025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking trabectedin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.