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Tovorafenib Side Effects

The most commonly reported side effects of tovorafenib include rash, accidental underdose, and disease progression, based on 248 FDA adverse event reports from 2024 to 2025.

Tovorafenib side effects

Percentages show how often each reaction appears relative to total reports for tovorafenib.

1
Rash8.9%22
2
Accidental Underdose7.7%19
3
Disease Progression6.9%17
4
Off Label Use6.5%16
5
Fatigue6.5%16
6
Hair Colour Changes5.6%14
7
Headache5.2%13
8
Blood Creatine Phosphokinase Increased4.4%11
9
Melanocytic Naevus4.4%11
10
Acne4.0%10
11
Intracranial Tumour Haemorrhage3.6%9
12
Dermatitis Acneiform3.2%8
13
Growth Retardation3.2%8
14
Nausea2.8%7
15
Blood Phosphorus Decreased2.4%6

These are voluntary reports and do not establish that tovorafenib caused these reactions.

Report severity

28.6%Serious71 reports
10.1%Hospitalizations25 reports
2.8%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tovorafenib drug interactions

Other drugs that appear in adverse event reports alongside tovorafenib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Trametinib0.8%2
2
Temozolomide0.8%2
3
Levetiracetam0.8%2
4
Nivolumab0.4%1
5
Relatlimab-rmbw0.4%1
6
Famotidine0.4%1
7
Vigabatrin0.4%1
8
Acetaminophen0.4%1
9
Hydrocodone0.4%1
10
Dabrafenib-mesylate0.4%1

Taken alongside

1
Levetiracetam2.8%7
2
Acetaminophen2.4%6
3
Ondansetron2.0%5
4
Desmopressin-acetate1.6%4
5
Triamcinolone1.2%3
6
Sertraline-hydrochloride1.2%3
7
Levothyroxine-sodium1.2%3
8
Famotidine0.8%2
9
Cyproheptadine-hydrochloride0.8%2
10
Minocycline-hydrochloride0.8%2
11
Acetazolamide0.8%2
12
Polyethylene-glycol-33500.8%2
13
Sulfamethoxazole0.8%2
14
Trimethoprim0.8%2
15
Ergocalciferol0.8%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tovorafenib side effects

5.6% of tovorafenib adverse event reports involve female patients and 3.6% involve male patients. The largest age group is child at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female5.6%
Male3.6%
Unknown90.7%

Age group

< 22.9%
2–1161.8%
12–1714.7%
18–6417.6%
65+2.9%

What is tovorafenib used for

Conditions and purposes for which patients were taking tovorafenib when the adverse event was reported.

Acinar Cell Carcinoma Of PancreasAstrocytomaAstrocytoma MalignantAstrocytoma, Low GradeBrain NeoplasmBrain Neoplasm BenignBrain Neoplasm MalignantCentral Nervous System NeoplasmGangliogliomaGlioblastomaGliomaGlioneuronal TumourLangerhans^ Cell HistiocytosisMalignant Neoplasm Of Spinal CordMetastases To Meninges

Showing 15 of 22 indications

Tovorafenib brand names and reporting trend

Tovorafenib is sold under the brand name Ojemda.

Brand names

Ojemda16

Quarterly reports (20242025)

20242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tovorafenib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.