The most commonly reported side effects of topotecan include off label use, febrile neutropenia, and death, based on 6,959 FDA adverse event reports from 2004 to 2025. 4.1% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for topotecan.
These are voluntary reports and do not establish that topotecan caused these reactions.
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Other drugs that appear in adverse event reports alongside topotecan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
49.9% of topotecan adverse event reports involve female patients and 32.9% involve male patients. The largest age group is adult at 38%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking topotecan when the adverse event was reported.
Showing 15 of 509 indications
Topotecan is sold under the brand name Hycamtin.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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