The most commonly reported side effects of tolvaptan include death, off label use, and renal impairment, based on 13,491 FDA adverse event reports from 2005 to 2025.
Percentages show how often each reaction appears relative to total reports for tolvaptan.
These are voluntary reports and do not establish that tolvaptan caused these reactions.
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Other drugs that appear in adverse event reports alongside tolvaptan. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
41.2% of tolvaptan adverse event reports involve female patients and 42.1% involve male patients. The largest age group is elderly at 50%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking tolvaptan when the adverse event was reported.
Showing 15 of 423 indications
Tolvaptan is sold under the brand name Tolvaptan.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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