OpenClaim

Tolterodine Side Effects

The most commonly reported side effects of tolterodine include fatigue, fall, and diarrhoea, based on 20,250 FDA adverse event reports from 2004 to 2025. 6.1% of reports found the drug to be ineffective.

Tolterodine side effects

Percentages show how often each reaction appears relative to total reports for tolterodine.

1
Drug Ineffective6.1%1,241
2
Drug Ineffective4.9%984
3
Fatigue4.0%812
4
Fall3.9%784
5
Diarrhoea3.1%622
6
Nausea2.7%553
7
Dizziness2.7%547
8
Pain2.6%523
9
Headache2.6%521
10
Dry Mouth2.4%476
11
Nausea2.3%474
12
Dizziness2.3%473
13
Off Label Use2.3%465
14
Fall2.3%464
15
Asthenia2.2%444

These are voluntary reports and do not establish that tolterodine caused these reactions.

Report severity

64.2%Serious13,001 reports
28.7%Hospitalizations5,803 reports
6.4%Fatal1,294 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tolterodine drug interactions

Other drugs that appear in adverse event reports alongside tolterodine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dalfampridine4.1%825
2
Interferon3.7%752
3
Adalimumab2.7%547
4
Dimethyl2.2%439
5
Lenalidomide2.0%415
6
Omeprazole1.8%361
7
Pregabalin1.8%359
8
Sodium-oxybate1.6%319
9
Esomeprazole1.5%307
10
Natalizumab1.5%296
11
Fingolimod1.4%289
12
Atorvastatin-calcium1.4%286
13
Gabapentin1.3%271
14
Etanercept1.3%269
15
Oxybutynin1.3%265

Taken alongside

1
Aspirin15.7%3,179
2
Acetaminophen15.4%3,113
3
Levothyroxine-sodium14.4%2,912
4
Ergocalciferol13.0%2,633
5
Gabapentin11.6%2,357
6
Omeprazole11.5%2,335
7
Atorvastatin-calcium11.4%2,314
8
Furosemide9.4%1,894
9
Amlodipine8.8%1,774
10
Lisinopril8.6%1,751
11
Albuterol8.6%1,745
12
Metoprolol8.5%1,721
13
Simvastatin8.5%1,714
14
Hydrochlorothiazide8.0%1,623
15
Metformin7.9%1,596

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tolterodine side effects

72.6% of tolterodine adverse event reports involve female patients and 21.6% involve male patients. The largest age group is elderly at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female72.6%
Male21.6%
Unknown5.8%

Age group

< 2<0.1%
2–110.4%
12–170.3%
18–6444.5%
65+54.7%

What is tolterodine used for

Conditions and purposes for which patients were taking tolterodine when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal Pain LowerAbdominal Pain UpperAbdominal RigidityAccidentAcute Kidney InjuryAnal IncontinenceAngle Closure GlaucomaAnticholinergic SyndromeArthritisAtonic Urinary BladderAtrioventricular Block CompleteAutomatic BladderAcute Kidney Injury

Showing 15 of 232 indications

Tolterodine brand names and reporting trend

Tolterodine is sold under the brand name Detrol La.

Brand names

Detrol La84

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tolterodine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.