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Tolmetin Side Effects

The most commonly reported side effects of tolmetin include drug hypersensitivity, fatigue, and headache, based on 262 FDA adverse event reports from 2004 to 2025. 2.7% of reports found the drug to be ineffective.

Tolmetin side effects

Percentages show how often each reaction appears relative to total reports for tolmetin.

1
Drug Hypersensitivity25.2%66
2
Fatigue5.3%14
3
Headache4.6%12
4
Renal Failure4.2%11
5
Nausea4.2%11
6
Urticaria4.2%11
7
Pain3.8%10
8
Arthralgia3.4%9
9
Dizziness3.4%9
10
Nausea3.4%9
11
Asthenia3.4%9
12
Diarrhoea3.4%9
13
Dyspnoea3.1%8
14
Chronic Kidney Disease3.1%8
15
Drug Ineffective2.7%7

These are voluntary reports and do not establish that tolmetin caused these reactions.

Report severity

47.3%Serious124 reports
21.4%Hospitalizations56 reports
4.2%Fatal11 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tolmetin drug interactions

Other drugs that appear in adverse event reports alongside tolmetin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Naproxen12.6%33
2
Ibuprofen12.6%33
3
Diclofenac9.2%24
4
Etanercept8.8%23
5
Adalimumab8.4%22
6
Indomethacin8.0%21
7
Sulindac7.6%20
8
Piroxicam7.3%19
9
Aspirin6.9%18
10
Acetaminophen6.9%18
11
Ketoprofen6.5%17
12
Ketorolac-tromethamine5.7%15
13
Nabumetone5.7%15
14
Oxaprozin5.0%13
15
Meloxicam5.0%13

Taken alongside

1
Acetaminophen21.4%56
2
Methotrexate13.4%35
3
Prednisone12.6%33
4
Hydrocodone11.1%29
5
Gabapentin10.7%28
6
Lisinopril10.7%28
7
Aspirin10.7%28
8
Albuterol9.9%26
9
Folic-acid9.5%25
10
Cyclobenzaprine-hydrochloride8.8%23
11
Oxycodone8.0%21
12
Tramadol-hydrochloride7.6%20
13
Hydrochlorothiazide7.6%20
14
Ranitidine7.3%19
15
Amlodipine7.3%19

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tolmetin side effects

68.3% of tolmetin adverse event reports involve female patients and 21.4% involve male patients. The largest age group is adult at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female68.3%
Male21.4%
Unknown10.3%

Age group

< 20.0%
2–111.9%
12–173.7%
18–6454.9%
65+39.5%

What is tolmetin used for

Conditions and purposes for which patients were taking tolmetin when the adverse event was reported.

Allergy TestAnkylosing SpondylitisAntiinflammatory TherapyArthralgiaArthritisAnalgesic TherapyDrug Use For Unknown IndicationGoutHaematomaIll-defined DisorderInflammationJuvenile ArthritisJuvenile Idiopathic ArthritisLimb InjuryMast Cell Activation Syndrome

Showing 15 of 26 indications

Tolmetin brand names and reporting trend

Tolmetin is sold under the brand name Tolectin Ds.

Brand names

Tolectin Ds176

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tolmetin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.