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Tocopherol Side Effects

The most commonly reported side effects of tocopherol include macular degeneration, dyspnoea, and nausea, based on 900 FDA adverse event reports from 2004 to 2025. 26.2% of reports found the drug to be ineffective.

Tocopherol side effects

Percentages show how often each reaction appears relative to total reports for tocopherol.

1
Drug Ineffective26.2%236
2
Macular Degeneration22.6%203
3
Dyspnoea18.9%170
4
Nausea15.8%142
5
Therapeutic Product Effect Incomplete15.4%139
6
Weight Decreased13.8%124
7
Pain13.4%121
8
Off Label Use12.7%114
9
Headache11.6%104
10
Infusion Related Reaction11.6%104
11
Wheezing11.4%103
12
Anaemia11.3%102
13
Malaise11.3%102
14
Dyspepsia11.0%99
15
Abdominal Pain10.9%98

These are voluntary reports and do not establish that tocopherol caused these reactions.

Report severity

93.2%Serious839 reports
47.7%Hospitalizations429 reports
12.3%Fatal111 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tocopherol drug interactions

Other drugs that appear in adverse event reports alongside tocopherol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ergocalciferol35.6%320
2
Fluticasone33.3%300
3
Prednisone28.1%253
4
Betamethasone27.2%245
5
Calcium-carbonate27.2%245
6
Budesonide27.1%244
7
Azithromycin26.1%235
8
Aspirin25.7%231
9
Hydrochlorothiazide25.4%229
10
Sodium-chloride25.3%228
11
Pantoprazole-sodium25.0%225
12
Clotrimazole24.7%222
13
Metronidazole23.6%212
14
Cholecalciferol23.2%209
15
Acetaminophen23.1%208

Taken alongside

1
Ergocalciferol17.1%154
2
Acetaminophen15.3%138
3
Valsartan14.1%127
4
Cholecalciferol13.1%118
5
Ascorbic-acid10.8%97
6
Calcium10.3%93
7
Aspirin9.7%87
8
Calcium-carbonate9.1%82
9
Levothyroxine-sodium8.8%79
10
Diphenhydramine8.8%79
11
Rosuvastatin8.4%76
12
Omeprazole8.2%74
13
Cyanocobalamin7.9%71
14
Pantoprazole-sodium7.7%69
15
Atorvastatin-calcium7.3%66

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tocopherol side effects

51.8% of tocopherol adverse event reports involve female patients and 36.2% involve male patients. The largest age group is elderly at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.8%
Male36.2%
Unknown12.0%

Age group

< 25.0%
2–111.5%
12–171.1%
18–6437.3%
65+55.1%

What is tocopherol used for

Conditions and purposes for which patients were taking tocopherol when the adverse event was reported.

Antioxidant TherapyArteriosclerosisAmyotrophic Lateral SclerosisAnti-soluble Liver Antigen/liver Pancreas AntibodyBulbospinal Muscular Atrophy CongenitalChronic Hepatitis CCongenital MegacolonCardiovascular DisorderConstipationCystic FibrosisDehydrationDiarrhoeaDizzinessDrug Use For Unknown IndicationDyslipidaemia

Showing 15 of 58 indications

Tocopherol brand names and reporting trend

Tocopherol is sold under the brand name Infuvite Pediatric.

Brand names

Infuvite Pediatric1,078

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tocopherol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.