OpenClaim

Tobramycin Side Effects

The most commonly reported side effects of tobramycin include off label use, death, and pneumonia, based on 28,760 FDA adverse event reports from 2004 to 2025. 3.6% of reports found the drug to be ineffective.

Tobramycin side effects

Percentages show how often each reaction appears relative to total reports for tobramycin.

1
Off Label Use7.6%2,189
2
Death5.4%1,546
3
Pneumonia5.2%1,506
4
Infective Pulmonary Exacerbation Of Cystic Fibrosis5.2%1,489
5
Dyspnoea4.8%1,382
6
Cystic Fibrosis4.5%1,280
7
Cough4.3%1,248
8
Hospitalisation4.0%1,138
9
Drug Ineffective3.6%1,021
10
Condition Aggravated3.5%999
11
Infection2.9%839
12
Acute Kidney Injury2.9%830
13
Fatigue2.5%721
14
Headache2.4%701
15
Malaise2.4%695

These are voluntary reports and do not establish that tobramycin caused these reactions.

Report severity

75.4%Serious21,699 reports
45.0%Hospitalizations12,930 reports
11.2%Fatal3,207 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tobramycin drug interactions

Other drugs that appear in adverse event reports alongside tobramycin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ivacaftor14.0%4,026
2
Aztreonam6.8%1,958
3
Dexamethasone5.8%1,664
4
Lumacaftor4.5%1,304
5
Elexacaftor-ivacaftor-tezacaftor3.9%1,115
6
Dornase-alfa3.5%1,020
7
Vancomycin3.0%864
8
Ciprofloxacin2.0%573
9
Omeprazole1.7%476
10
Meropenem1.6%457
11
Dupilumab1.3%383
12
Prednisone1.2%356
13
Esomeprazole1.2%350
14
Azithromycin1.2%347
15
Ceftazidime1.1%324

Taken alongside

1
Albuterol22.4%6,441
2
Dornase-alfa20.4%5,859
3
Lipase15.9%4,576
4
Pancrelipase-amylase15.2%4,378
5
Protease15.2%4,377
6
Azithromycin13.0%3,752
7
Fluticasone12.7%3,645
8
Ergocalciferol10.7%3,065
9
Sodium-chloride10.3%2,952
10
Dexamethasone9.5%2,743
11
Acetaminophen8.6%2,464
12
Omeprazole8.0%2,292
13
Prednisone7.5%2,146
14
Montelukast-sodium6.5%1,880
15
Budesonide6.5%1,872

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tobramycin side effects

50.8% of tobramycin adverse event reports involve female patients and 40.2% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.8%
Male40.2%
Unknown9.0%

Age group

< 22.0%
2–119.3%
12–179.7%
18–6453.8%
65+25.1%

What is tobramycin used for

Conditions and purposes for which patients were taking tobramycin when the adverse event was reported.

Abdominal InfectionAbdominal PainAbdominal Pain UpperAbscessAbscess LimbAcanthamoeba KeratitisAccidentAccident At HomeAcetabulum FractureAcid Fast Bacilli InfectionAcinetobacter BacteraemiaAcinetobacter InfectionAcneAcute Kidney InjuryAcute Leukaemia

Showing 15 of 1,095 indications

Tobramycin brand names and reporting trend

Tobramycin is sold under brand names including Kitabis Pak, Nebcin.

Brand names

Kitabis Pak14,387
Nebcin478

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tobramycin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.