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Tisotumab Side Effects

The most commonly reported side effects of tisotumab include neuropathy peripheral, malignant neoplasm progression, and nausea, based on 809 FDA adverse event reports from 2019 to 2025.

Tisotumab side effects

Percentages show how often each reaction appears relative to total reports for tisotumab.

1
Neuropathy Peripheral7.5%61
2
Malignant Neoplasm Progression6.9%56
3
Nausea6.6%53
4
Dry Eye5.7%46
5
Off Label Use4.7%38
6
Rash4.3%35
7
Death4.1%33
8
Conjunctivitis3.8%31
9
Diarrhoea3.8%31
10
Fatigue3.7%30
11
Eye Disorder3.5%28
12
Anaemia3.1%25
13
Weight Decreased3.0%24
14
Pyrexia2.7%22
15
Epistaxis2.7%22

These are voluntary reports and do not establish that tisotumab caused these reactions.

Report severity

58.8%Serious476 reports
23.7%Hospitalizations192 reports
7.7%Fatal62 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tisotumab drug interactions

Other drugs that appear in adverse event reports alongside tisotumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Carboplatin7.9%64
2
Pembrolizumab6.6%53
3
Bevacizumab4.9%40
4
Paclitaxel1.9%15
5
Cetuximab0.7%6
6
Apixaban0.6%5
7
Nivolumab0.5%4
8
Cisplatin0.5%4
9
Brentuximab-vedotin0.4%3
10
Oxycodone0.4%3
11
Doxorubicin-hydrochloride0.2%2
12
Dexamethasone0.2%2
13
Rivaroxaban0.2%2
14
Gemfibrozil0.2%2
15
Aspirin0.2%2

Taken alongside

1
Acetaminophen6.3%51
2
Ondansetron4.4%36
3
Dexamethasone4.4%36
4
Oxycodone4.0%32
5
Brimonidine-tartrate3.5%28
6
Apixaban2.6%21
7
Apomorphine-hydrochloride2.5%20
8
Lorazepam2.3%19
9
Gabapentin2.2%18
10
Metoclopramide-hydrochloride2.2%18
11
Loperamide-hydrochloride2.2%18
12
Tramadol-hydrochloride2.1%17
13
Ibuprofen2.1%17
14
Omeprazole2.0%16
15
Morphine-sulfate2.0%16

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tisotumab side effects

78.6% of tisotumab adverse event reports involve female patients and 2.5% involve male patients. The largest age group is adult at 82%. These figures reflect who reports side effects, not underlying risk.

Sex

Female78.6%
Male2.5%
Unknown18.9%

Age group

< 20.0%
2–110.0%
12–170.5%
18–6481.8%
65+17.6%

What is tisotumab used for

Conditions and purposes for which patients were taking tisotumab when the adverse event was reported.

Adenocarcinoma Of The CervixAdenocarcinoma PancreasAdenosquamous Carcinoma Of The CervixAgranulocytosisCervix Cancer MetastaticCervix CarcinomaCervix Cancer MetastaticCervix CarcinomaCervix Carcinoma RecurrentCervix Carcinoma Stage IiiCervix Carcinoma Stage IvClear Cell Carcinoma Of CervixEndometrial AdenocarcinomaEndometrial CancerEndometrial Neoplasm

Showing 15 of 39 indications

Tisotumab brand names and reporting trend

Tisotumab is sold under the brand name Tivdak.

Brand names

Tivdak212

Quarterly reports (20192025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tisotumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.