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Tiotropium Side Effects

The most commonly reported side effects of tiotropium include dyspnoea, incorrect route of drug administration, and asthma, based on 158,212 FDA adverse event reports from 2004 to 2025. 5.1% of reports found the drug to be ineffective.

Tiotropium side effects

Percentages show how often each reaction appears relative to total reports for tiotropium.

1
Dyspnoea14.2%22,410
2
Incorrect Route Of Drug Administration9.2%14,583
3
Asthma8.0%12,584
4
Cough5.8%9,133
5
Incorrect Route Of Drug Administration5.5%8,748
6
Pneumonia5.5%8,692
7
Drug Ineffective5.1%8,008
8
Wheezing4.9%7,712
9
Chronic Obstructive Pulmonary Disease4.0%6,346
10
Product Quality Issue3.9%6,238
11
Off Label Use3.6%5,737
12
Fatigue3.6%5,661
13
Malaise3.0%4,735
14
Therapeutic Product Effect Incomplete2.9%4,655
15
Fall2.6%4,155

These are voluntary reports and do not establish that tiotropium caused these reactions.

Report severity

52.5%Serious83,138 reports
30.2%Hospitalizations47,840 reports
7.4%Fatal11,747 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tiotropium drug interactions

Other drugs that appear in adverse event reports alongside tiotropium. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Albuterol7.2%11,317
2
Fluticasone5.8%9,199
3
Budesonide5.1%8,021
4
Formoterol4.5%7,161
5
Mepolizumab4.0%6,371
6
Salmeterol-xinafoate3.8%5,996
7
Prednisone3.6%5,766
8
Montelukast-sodium3.4%5,325
9
Omalizumab3.2%5,116
10
Ipratropium-bromide2.5%3,907
11
Dupilumab1.9%3,035
12
Vilanterol-trifenatate1.9%3,006
13
Olodaterol-hydrochloride1.8%2,906
14
Ciclesonide1.8%2,811
15
Furosemide1.7%2,698

Taken alongside

1
Albuterol27.1%42,894
2
Fluticasone16.3%25,830
3
Budesonide11.4%17,971
4
Formoterol11.3%17,822
5
Salmeterol-xinafoate11.2%17,742
6
Aspirin10.8%17,091
7
Furosemide9.8%15,556
8
Montelukast-sodium9.0%14,203
9
Acetaminophen8.8%13,934
10
Prednisone8.5%13,419
11
Omeprazole7.8%12,307
12
Atorvastatin-calcium7.6%11,984
13
Levothyroxine-sodium7.2%11,402
14
Ergocalciferol6.5%10,247
15
Pantoprazole-sodium5.6%8,886

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tiotropium side effects

55.9% of tiotropium adverse event reports involve female patients and 37.1% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.9%
Male37.1%
Unknown6.9%

Age group

< 20.1%
2–110.2%
12–170.3%
18–6436.9%
65+62.6%

What is tiotropium used for

Conditions and purposes for which patients were taking tiotropium when the adverse event was reported.

Accidental ExposureAcute Respiratory Distress SyndromeAcute Respiratory FailureAddison^s DiseaseAdjuvant TherapyAllergic Granulomatous AngiitisAllergic Respiratory SymptomAllergy To AnimalAlpha 1 Globulin DecreasedAlpha-1 Anti-trypsin AbnormalAlpha-1 Anti-trypsin DeficiencyAlpha-1 Antitrypsin DeficiencyAlveolitisAlveolitis AllergicAnaemia

Showing 15 of 614 indications

Tiotropium brand names and reporting trend

Tiotropium is sold under the brand name Spiriva Respimat.

Brand names

Spiriva Respimat19,027

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tiotropium with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.