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Timolol Side Effects

The most commonly reported side effects of timolol include treatment failure, eye irritation, and eye pain, based on 38,692 FDA adverse event reports from 2004 to 2025. 6.3% of reports found the drug to be ineffective.

Timolol side effects

Percentages show how often each reaction appears relative to total reports for timolol.

1
Treatment Failure10.6%4,099
2
Drug Ineffective6.3%2,434
3
Eye Irritation5.3%2,061
4
Eye Pain4.3%1,665
5
Ocular Hyperaemia4.1%1,594
6
Fatigue4.0%1,558
7
Off Label Use3.3%1,296
8
Vision Blurred3.1%1,200
9
Diarrhoea2.8%1,096
10
Dizziness2.8%1,083
11
Intraocular Pressure Increased2.6%1,024
12
Death2.6%1,015
13
Hypersensitivity2.6%990
14
Headache2.5%973
15
Nausea2.5%950

These are voluntary reports and do not establish that timolol caused these reactions.

Report severity

48.9%Serious18,929 reports
20.2%Hospitalizations7,801 reports
5.8%Fatal2,253 reports

Seriousness is determined by the reporter, not by OpenClaim.

Timolol drug interactions

Other drugs that appear in adverse event reports alongside timolol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Brimonidine-tartrate16.0%6,176
2
Dorzolamide-hydrochloride14.0%5,406
3
Latanoprost9.6%3,702
4
Bimatoprost6.0%2,314
5
Travoprost3.8%1,482
6
Lenalidomide3.8%1,455
7
Brinzolamide3.2%1,247
8
Cenegermin-bkbj2.7%1,028
9
Adalimumab2.4%928
10
Dexamethasone1.1%432
11
Etanercept1.1%419
12
Methotrexate0.9%334
13
Prednisone0.9%333
14
Prednisolone0.9%332
15
Pomalidomide0.8%315

Taken alongside

1
Brimonidine-tartrate17.8%6,880
2
Dorzolamide-hydrochloride16.1%6,237
3
Latanoprost15.9%6,147
4
Aspirin13.3%5,132
5
Ergocalciferol10.4%4,028
6
Acetaminophen9.6%3,725
7
Levothyroxine-sodium9.4%3,620
8
Atorvastatin-calcium9.3%3,602
9
Amlodipine9.2%3,556
10
Furosemide7.3%2,806
11
Omeprazole7.1%2,730
12
Metoprolol6.9%2,689
13
Bimatoprost6.7%2,595
14
Lisinopril6.5%2,522
15
Metformin5.7%2,220

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports timolol side effects

55.7% of timolol adverse event reports involve female patients and 38.2% involve male patients. The largest age group is elderly at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.7%
Male38.2%
Unknown6.1%

Age group

< 20.8%
2–110.6%
12–170.4%
18–6425.1%
65+73.2%

What is timolol used for

Conditions and purposes for which patients were taking timolol when the adverse event was reported.

Abnormal Sensation In EyeAcanthamoeba KeratitisAccidental ExposureAcute MyopiaAdverse EventAge-related Macular DegenerationAngina PectorisAngiolymphoid Hyperplasia With EosinophiliaAngle Closure GlaucomaAnkylosing SpondylitisAnxietyAphakiaApraxiaArrhythmiaArthralgia

Showing 15 of 425 indications

Timolol brand names and reporting trend

Timolol is sold under brand names including Betimol, Combigan.

Brand names

Betimol22,460
Combigan44

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking timolol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.