OpenClaim

Tigecycline Side Effects

The most commonly reported side effects of tigecycline include off label use, nausea, and vomiting, based on 5,997 FDA adverse event reports from 2005 to 2025. 10.4% of reports found the drug to be ineffective.

Tigecycline side effects

Percentages show how often each reaction appears relative to total reports for tigecycline.

1
Off Label Use10.8%650
2
Drug Ineffective10.4%622
3
Nausea5.4%322
4
Vomiting3.7%221
5
Thrombocytopenia3.6%218
6
Sepsis3.5%207
7
Drug Resistance3.4%203
8
Coagulopathy3.1%188
9
Septic Shock3.1%187
10
Death3.0%180
11
Diarrhoea2.9%174
12
Pathogen Resistance2.9%172
13
Product Use In Unapproved Indication2.8%167
14
Condition Aggravated2.7%163
15
Acute Kidney Injury2.7%160

These are voluntary reports and do not establish that tigecycline caused these reactions.

Report severity

92.6%Serious5,556 reports
40.2%Hospitalizations2,412 reports
27.1%Fatal1,623 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tigecycline drug interactions

Other drugs that appear in adverse event reports alongside tigecycline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Meropenem12.2%732
2
Linezolid9.8%588
3
Amikacin-sulfate9.6%573
4
Vancomycin8.3%496
5
Imipenem7.2%430
6
Azithromycin6.8%405
7
Ciprofloxacin5.6%337
8
Colistin-sulfate5.6%337
9
Daptomycin4.2%254
10
Clofazimine4.2%253
11
Metronidazole4.1%247
12
Fluconazole3.5%211
13
Levofloxacin3.3%196
14
Clarithromycin3.2%194
15
Moxifloxacin-hydrochloride3.2%193

Taken alongside

1
Meropenem10.1%605
2
Amikacin-sulfate6.8%405
3
Vancomycin6.0%358
4
Sodium-chloride5.3%319
5
Linezolid5.3%316
6
Furosemide5.2%310
7
Acetaminophen4.7%282
8
Omeprazole4.4%263
9
Pantoprazole-sodium4.0%239
10
Fluconazole4.0%239
11
Imipenem3.9%236
12
Azithromycin3.8%226
13
Insulin3.6%213
14
Metronidazole3.4%201
15
Albuterol3.3%196

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tigecycline side effects

38.0% of tigecycline adverse event reports involve female patients and 50.2% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.0%
Male50.2%
Unknown11.8%

Age group

< 21.4%
2–112.9%
12–172.1%
18–6453.5%
65+40.2%

What is tigecycline used for

Conditions and purposes for which patients were taking tigecycline when the adverse event was reported.

Abdominal AbscessAbdominal InfectionAbdominal InjuryAbdominal OperationAbdominal SepsisAbdominal Wall InfectionAbdominal Wall MassAbdominal Wound DehiscenceAbscessAbscess BacterialAbscess IntestinalAbscess LimbAbscess NeckAcinetobacter BacteraemiaAcinetobacter Infection

Showing 15 of 646 indications

Tigecycline brand names and reporting trend

Tigecycline is sold under the brand name Tigecycline.

Brand names

Tigecycline5,668

Quarterly reports (20052025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tigecycline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.