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Thyrotropin Side Effects

The most commonly reported side effects of thyrotropin include nausea, fatigue, and headache, based on 998 FDA adverse event reports from 2004 to 2025. 3.4% of reports found the drug to be ineffective.

Thyrotropin side effects

Percentages show how often each reaction appears relative to total reports for thyrotropin.

1
Nausea9.5%95
2
Fatigue7.1%71
3
Headache6.7%67
4
Off Label Use6.5%65
5
Malaise3.5%35
6
Drug Ineffective3.4%34
7
Nausea3.2%32
8
Vomiting3.2%32
9
Pain3.1%31
10
Blood Thyroid Stimulating Hormone Decreased2.7%27
11
Dizziness2.7%27
12
Product Storage Error2.3%23
13
Drug Administered At Inappropriate Site2.2%22
14
Pyrexia2.1%21
15
Oropharyngeal Pain2.0%20

These are voluntary reports and do not establish that thyrotropin caused these reactions.

Report severity

35.5%Serious354 reports
16.1%Hospitalizations161 reports
2.3%Fatal23 reports

Seriousness is determined by the reporter, not by OpenClaim.

Thyrotropin drug interactions

Other drugs that appear in adverse event reports alongside thyrotropin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dupilumab1.9%19
2
Sodium-iodide-i-1311.0%10
3
Methotrexate0.9%9
4
Prednisone0.8%8
5
Rituximab0.8%8
6
Tocilizumab0.8%8
7
Undecoylium-chloride-iodine-complex0.7%7
8
Adalimumab0.7%7
9
Lenalidomide0.7%7
10
Levothyroxine-sodium0.6%6
11
Fluticasone0.6%6
12
Triamcinolone0.5%5
13
Nicotine0.5%5
14
Morphine-sulfate0.5%5
15
Pomalidomide0.4%4

Taken alongside

1
Levothyroxine-sodium15.6%156
2
Ergocalciferol2.8%28
3
Acetaminophen2.6%26
4
Omeprazole2.5%25
5
Prednisone2.0%20
6
Gabapentin1.9%19
7
Undecoylium-chloride-iodine-complex1.9%19
8
Calcium1.7%17
9
Aspirin1.7%17
10
Metformin1.6%16
11
Ranitidine1.6%16
12
Metoprolol1.5%15
13
Albuterol1.4%14
14
Amlodipine1.4%14
15
Hydroxychloroquine-sulfate1.3%13

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports thyrotropin side effects

57.8% of thyrotropin adverse event reports involve female patients and 19.8% involve male patients. The largest age group is adult at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.8%
Male19.8%
Unknown22.3%

Age group

< 20.0%
2–110.5%
12–171.2%
18–6480.5%
65+17.8%

What is thyrotropin used for

Conditions and purposes for which patients were taking thyrotropin when the adverse event was reported.

Adjuvant TherapyAnti-thyroid AntibodyAutoimmune ThyroiditisBreast CancerBasedow^s DiseaseBenign Breast NeoplasmBlood Thyroid Stimulating HormoneBlood Thyroid Stimulating Hormone IncreasedBrain Neoplasm MalignantBreast CancerDiagnostic ProcedureDrug Use For Unknown IndicationDiagnostic ProcedureEndocrine DisorderFollicular Thyroid Cancer

Showing 15 of 67 indications

Thyrotropin brand names and reporting trend

Thyrotropin is sold under the brand name Thyrogen.

Brand names

Thyrogen86

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking thyrotropin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.