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Thiothixene Side Effects

The most commonly reported side effects of thiothixene include diabetes mellitus, type 2 diabetes mellitus, and blood cholesterol increased, based on 1,023 FDA adverse event reports from 2004 to 2025. 3.5% of reports found the drug to be ineffective.

Thiothixene side effects

Percentages show how often each reaction appears relative to total reports for thiothixene.

1
Diabetes Mellitus19.3%197
2
Type 2 Diabetes Mellitus15.0%153
3
Blood Cholesterol Increased6.3%64
4
Obesity5.6%57
5
Pancreatitis5.5%56
6
Weight Increased5.4%55
7
Hyperglycaemia5.0%51
8
Tardive Dyskinesia4.9%50
9
Diabetes Mellitus Inadequate Control4.9%50
10
Nausea4.4%45
11
Blood Triglycerides Increased4.2%43
12
Diabetic Neuropathy4.2%43
13
Hypertension4.1%42
14
Diabetic Ketoacidosis3.7%38
15
Hyperlipidaemia3.6%37

These are voluntary reports and do not establish that thiothixene caused these reactions.

Report severity

69.0%Serious706 reports
30.3%Hospitalizations310 reports
6.2%Fatal63 reports

Seriousness is determined by the reporter, not by OpenClaim.

Thiothixene drug interactions

Other drugs that appear in adverse event reports alongside thiothixene. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate29.8%305
2
Olanzapine12.6%129
3
Risperidone5.2%53
4
Aripiprazole5.1%52
5
Haloperidol3.3%34
6
Lithium2.8%29
7
Ziprasidone2.7%28
8
Clozapine2.6%27
9
Varenicline2.6%27
10
Divalproex-sodium2.4%25
11
Paliperidone2.1%21
12
Valbenazine1.8%18
13
Chlorpromazine1.7%17
14
Fluoxetine-hydrochloride1.5%15
15
Lorazepam1.5%15

Taken alongside

1
Risperidone20.7%212
2
Haloperidol19.5%199
3
Olanzapine16.7%171
4
Aripiprazole15.3%157
5
Divalproex-sodium14.8%151
6
Benztropine-mesylate14.5%148
7
Clonazepam14.1%144
8
Lorazepam13.3%136
9
Ziprasidone12.8%131
10
Chlorpromazine11.9%122
11
Trazodone-hydrochloride11.5%118
12
Levothyroxine-sodium10.9%111
13
Metformin10.7%109
14
Acetaminophen10.5%107
15
Gabapentin10.2%104

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports thiothixene side effects

53.5% of thiothixene adverse event reports involve female patients and 41.0% involve male patients. The largest age group is adult at 85%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.5%
Male41.0%
Unknown5.6%

Age group

< 20.0%
2–110.1%
12–171.3%
18–6485.3%
65+13.2%

What is thiothixene used for

Conditions and purposes for which patients were taking thiothixene when the adverse event was reported.

Abnormal BehaviourAdolescenceAffective DisorderAgitationAnxietyAttention Deficit/hyperactivity DisorderAntipsychotic TherapyBipolar DisorderBipolar I DisorderBlood PressureBipolar I DisorderBipolar DisorderCerebral DisorderCryingChest Pain

Showing 15 of 78 indications

Thiothixene brand names and reporting trend

Thiothixene is sold under the brand name Thiothixene.

Brand names

Thiothixene399

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking thiothixene with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.