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Thioridazine Side Effects

The most commonly reported side effects of thioridazine include toxicity to various agents, weight increased, and obsessive-compulsive disorder, based on 1,401 FDA adverse event reports from 2004 to 2025. 16.8% of reports found the drug to be ineffective.

Thioridazine side effects

Percentages show how often each reaction appears relative to total reports for thioridazine.

1
Drug Ineffective16.8%236
2
Toxicity To Various Agents12.7%178
3
Weight Increased12.2%171
4
Obsessive-compulsive Disorder11.5%161
5
Suicide Attempt11.4%160
6
Akathisia11.3%159
7
Increased Appetite10.8%152
8
Euphoric Mood10.8%152
9
Antipsychotic Drug Level Below Therapeutic10.8%151
10
Disinhibition10.8%151
11
Leukopenia10.3%145
12
Therapeutic Product Effect Incomplete10.1%142
13
Therapeutic Product Effect Variable10.1%142
14
Hypertension6.4%90
15
Product Use In Unapproved Indication6.1%85

These are voluntary reports and do not establish that thioridazine caused these reactions.

Report severity

85.7%Serious1,201 reports
41.3%Hospitalizations579 reports
14.1%Fatal197 reports

Seriousness is determined by the reporter, not by OpenClaim.

Thioridazine drug interactions

Other drugs that appear in adverse event reports alongside thioridazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate20.8%292
2
Olanzapine19.3%271
3
Risperidone18.8%263
4
Haloperidol18.1%254
5
Clozapine17.4%244
6
Lithium14.3%200
7
Aripiprazole13.1%183
8
Fluoxetine-hydrochloride12.9%181
9
Perphenazine12.9%181
10
Trifluoperazine-hydrochloride12.0%168
11
Gabapentin11.8%165
12
Amisulpride11.8%165
13
Clomipramine-hydrochloride11.5%161
14
Loxapine11.3%159
15
Ziprasidone11.3%158

Taken alongside

1
Valproate-sodium8.6%120
2
Levothyroxine-sodium6.9%96
3
Risperidone6.5%91
4
Clonazepam5.9%82
5
Aripiprazole5.9%82
6
Lorazepam5.7%80
7
Fluoxetine-hydrochloride5.7%80
8
Omeprazole5.6%79
9
Acetaminophen5.4%75
10
Haloperidol5.1%71
11
Lithium5.1%71
12
Olanzapine5.0%70
13
Diazepam4.9%69
14
Quetiapine-fumarate4.6%65
15
Metformin4.6%64

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports thioridazine side effects

45.7% of thioridazine adverse event reports involve female patients and 44.2% involve male patients. The largest age group is adult at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.7%
Male44.2%
Unknown10.1%

Age group

< 20.6%
2–112.9%
12–172.7%
18–6470.8%
65+23.0%

What is thioridazine used for

Conditions and purposes for which patients were taking thioridazine when the adverse event was reported.

Abnormal BehaviourAcute Myeloid LeukaemiaAcute PsychosisAffective DisorderAggressionAgitationAmnestic DisorderAngelman's SyndromeAntibiotic TherapyAnxietyAstheniaAutism Spectrum DisorderAbnormal BehaviourAffective DisorderAntipsychotic Therapy

Showing 15 of 115 indications

Thioridazine brand names and reporting trend

Thioridazine is sold under brand names including Mellaril-s, Mellaril.

Brand names

Mellaril-s1,159
Mellaril9

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking thioridazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.