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Thioguanine Side Effects

The most commonly reported side effects of thioguanine include febrile neutropenia, haematotoxicity, and off label use, based on 2,754 FDA adverse event reports from 2004 to 2025. 4.5% of reports found the drug to be ineffective.

Thioguanine side effects

Percentages show how often each reaction appears relative to total reports for thioguanine.

1
Febrile Neutropenia21.7%598
2
Haematotoxicity6.8%187
3
Off Label Use5.4%148
4
Pyrexia5.3%147
5
Neutropenia4.9%135
6
Drug Ineffective4.5%125
7
Sepsis4.2%115
8
Pancytopenia4.0%109
9
Thrombocytopenia4.0%109
10
Vomiting3.5%96
11
Febrile Bone Marrow Aplasia3.4%94
12
Anaemia3.1%85
13
Abdominal Pain2.8%77
14
Diarrhoea2.8%77
15
Pneumonia2.6%72

These are voluntary reports and do not establish that thioguanine caused these reactions.

Report severity

97.7%Serious2,690 reports
49.4%Hospitalizations1,360 reports
17.8%Fatal491 reports

Seriousness is determined by the reporter, not by OpenClaim.

Thioguanine drug interactions

Other drugs that appear in adverse event reports alongside thioguanine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cytarabine69.5%1,914
2
Methotrexate67.2%1,852
3
Vincristine-sulfate62.6%1,724
4
Cyclophosphamide61.0%1,681
5
Doxorubicin-hydrochloride47.5%1,308
6
Dexamethasone41.4%1,140
7
Mercaptopurine35.4%976
8
Daunorubicin31.3%861
9
Pegaspargase28.2%776
10
Asparaginase26.7%735
11
Prednisone21.5%592
12
Etoposide13.0%358
13
Prednisolone11.1%306
14
Hydrocortisone8.7%239
15
Adalimumab6.0%165

Taken alongside

1
Cytarabine6.6%182
2
Sulfamethoxazole5.5%152
3
Vincristine-sulfate5.4%149
4
Trimethoprim5.3%146
5
Methotrexate5.1%141
6
Cyclophosphamide4.9%135
7
Ondansetron4.9%134
8
Dexamethasone3.9%108
9
Mercaptopurine3.7%103
10
Doxorubicin-hydrochloride3.4%95
11
Daunorubicin2.8%78
12
Prednisone2.8%77
13
Asparaginase2.3%62
14
Acetaminophen2.2%61
15
Hydrocortisone2.0%55

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports thioguanine side effects

33.4% of thioguanine adverse event reports involve female patients and 47.2% involve male patients. The largest age group is child at 35%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.4%
Male47.2%
Unknown19.4%

Age group

< 23.2%
2–1135.5%
12–1725.5%
18–6431.2%
65+4.6%

What is thioguanine used for

Conditions and purposes for which patients were taking thioguanine when the adverse event was reported.

Acute Biphenotypic LeukaemiaAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Monocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RefractoryAcute Promyelocytic LeukaemiaAcute Undifferentiated LeukaemiaAnaplastic Large Cell Lymphoma T- And Null-cell TypesAstrocytomaAstrocytoma MalignantAstrocytoma, Low GradeAtaxia TelangiectasiaAcute Leukaemia

Showing 15 of 127 indications

Thioguanine brand names and reporting trend

Thioguanine is sold under the brand name Thioguanine.

Brand names

Thioguanine3,012

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking thioguanine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.