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Thiamylal Side Effects

The most commonly reported side effects of thiamylal include off label use, bradycardia, and hyperbilirubinaemia, based on 218 FDA adverse event reports from 2004 to 2025. 8.7% of reports found the drug to be ineffective.

#1 Reported: Off Label UseAll side effects ↓Top Co-Medication: SevofluraneDrug interactions ↓37% of Reports Are AdultDemographics ↓

Thiamylal side effects

Percentages show how often each reaction appears relative to total reports for thiamylal.

1
Drug Ineffective8.7%19
2
Off Label Use5.5%12
3
Bradycardia5.0%11
4
Hyperbilirubinaemia5.0%11
5
Renal Failure4.6%10
6
Blood Pressure Decreased4.1%9
7
Hypotension4.1%9
8
Bradycardia3.2%7
9
Cardiac Arrest3.2%7
10
Maternal Exposure During Pregnancy3.2%7
11
Drug Interaction3.2%7
12
Status Epilepticus3.2%7
13
Post Procedural Complication2.8%6
14
Drug Interaction2.8%6
15
Platelet Count Decreased2.8%6

These are voluntary reports and do not establish that thiamylal caused these reactions.

Report severity

93.1%Serious203 reports
40.4%Hospitalizations88 reports
7.3%Fatal16 reports

Seriousness is determined by the reporter, not by OpenClaim.

Thiamylal drug interactions

Other drugs that appear in adverse event reports alongside thiamylal. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sevoflurane21.6%47
2
Midazolam14.2%31
3
Fentanyl12.8%28
4
Levetiracetam12.4%27
5
Diazepam11.9%26
6
Phenytoin10.6%23
7
Propofol8.7%19
8
Rocuronium-bromide8.3%18
9
Phenobarbital-sodium8.3%18
10
Lacosamide7.8%17
11
Methylprednisolone7.3%16
12
Topiramate6.9%15
13
Vecuronium-bromide6.0%13
14
Remifentanil-hydrochloride6.0%13
15
Atropine5.5%12

Taken alongside

1
Fentanyl25.7%56
2
Oxygen17.0%37
3
Midazolam15.6%34
4
Vecuronium-bromide14.2%31
5
Sevoflurane13.8%30
6
Atropine13.3%29
7
Rocuronium-bromide10.6%23
8
Remifentanil-hydrochloride9.6%21
9
Diazepam9.2%20
10
Nitrous-oxide8.3%18
11
Propofol8.3%18
12
Lidocaine7.3%16
13
Cefazolin-sodium5.5%12
14
Phenobarbital-sodium5.5%12
15
Hydroxyzine5.0%11

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports thiamylal side effects

42.7% of thiamylal adverse event reports involve female patients and 47.7% involve male patients. The largest age group is adult at 37%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.7%
Male47.7%
Unknown9.6%

Age group

< 213.0%
2–1115.1%
12–172.7%
18–6437.3%
65+31.9%

What is thiamylal used for

Conditions and purposes for which patients were taking thiamylal when the adverse event was reported.

Acute Encephalitis With Refractory, Repetitive Partial SeizuresAnaesthesiaAnaesthesia ProcedureAcute Encephalitis With Refractory, Repetitive Partial SeizuresAnaesthesiaAnaesthesia ProcedureDrug Exposure During PregnancyDrug Use For Unknown IndicationElectroencephalogram AbnormalEncephalopathyEpilepsyEpilepsyFebrile ConvulsionFebrile Infection-related Epilepsy SyndromeFoetal Exposure During Pregnancy

Showing 15 of 36 indications

Thiamylal brand names and reporting trend

Thiamylal is sold under the brand name Surital.

Brand names

Surital255

Quarterly reports (2004–2025)

2005201020152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking thiamylal with another medication?

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