OpenClaim

Tezepelumab Side Effects

The most commonly reported side effects of tezepelumab include asthma, dyspnoea, and arthralgia, based on 6,627 FDA adverse event reports from 2005 to 2025. 8.2% of reports found the drug to be ineffective.

Tezepelumab side effects

Percentages show how often each reaction appears relative to total reports for tezepelumab.

1
Asthma15.7%1,041
2
Dyspnoea10.3%683
3
Drug Ineffective8.2%545
4
Arthralgia7.4%488
5
Pneumonia5.9%391
6
Cough5.3%350
7
Death4.2%281
8
Headache3.7%247
9
Fatigue3.7%243
10
Product Dose Omission Issue3.5%231
11
Wheezing3.4%225
12
Back Pain3.4%223
13
Rash3.3%222
14
Pain3.3%216
15
Dizziness2.9%195

These are voluntary reports and do not establish that tezepelumab caused these reactions.

Report severity

56.8%Serious3,765 reports
22.6%Hospitalizations1,498 reports
5.6%Fatal371 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tezepelumab drug interactions

Other drugs that appear in adverse event reports alongside tezepelumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dupilumab5.1%339
2
Budesonide3.3%216
3
Benralizumab2.9%191
4
Formoterol2.2%148
5
Albuterol1.2%78
6
Prednisone1.1%76
7
Mepolizumab1.1%74
8
Glycopyrrolate1.1%72
9
Omalizumab1.0%66
10
Fluticasone1.0%63
11
Montelukast-sodium0.9%62
12
Theophylline0.7%49
13
Tiotropium-bromide0.7%48
14
Omeprazole0.7%47
15
Terbutaline-sulfate0.6%42

Taken alongside

1
Albuterol17.4%1,152
2
Fluticasone10.3%685
3
Montelukast-sodium8.8%585
4
Budesonide8.1%539
5
Tiotropium-bromide7.6%501
6
Prednisone7.1%468
7
Formoterol7.0%466
8
Vilanterol-trifenatate6.6%436
9
Umeclidinium-bromide5.7%381
10
Ipratropium-bromide2.9%190
11
Ergocalciferol2.2%148
12
Ciclesonide2.0%134
13
Cetirizine-hydrochloride2.0%130
14
Salmeterol-xinafoate2.0%130
15
Epinephrine1.8%122

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tezepelumab side effects

60.2% of tezepelumab adverse event reports involve female patients and 22.1% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.2%
Male22.1%
Unknown17.7%

Age group

< 20.1%
2–110.2%
12–172.0%
18–6461.6%
65+36.1%

What is tezepelumab used for

Conditions and purposes for which patients were taking tezepelumab when the adverse event was reported.

Acute Post Asthmatic AmyotrophyAcute SinusitisAdverse Drug ReactionAllergic BronchitisAlpha-1 Antitrypsin DeficiencyAnkylosing SpondylitisAsthmaAsthma Exercise InducedAsthma Late OnsetAsthma ProphylaxisAsthma-chronic Obstructive Pulmonary Disease Overlap SyndromeAsthmatic CrisisBack PainBlood CholesterolBlood Immunoglobulin E Increased

Showing 15 of 78 indications

Tezepelumab brand names and reporting trend

Tezepelumab is sold under the brand name Tezspire.

Brand names

Tezspire2,426

Quarterly reports (20052025)

2005201020152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tezepelumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.