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Teriflunomide Side Effects

The most commonly reported side effects of teriflunomide include alopecia, multiple sclerosis relapse, and fatigue, based on 44,730 FDA adverse event reports from 2010 to 2025. 6.3% of reports found the drug to be ineffective.

Teriflunomide side effects

Percentages show how often each reaction appears relative to total reports for teriflunomide.

1
Alopecia13.6%6,069
2
Multiple Sclerosis Relapse11.6%5,211
3
Fatigue10.6%4,756
4
Diarrhoea10.6%4,746
5
Fall7.4%3,332
6
Hypoaesthesia7.1%3,167
7
Headache6.7%2,998
8
Drug Ineffective6.3%2,815
9
Paraesthesia6.3%2,809
10
Nausea6.1%2,748
11
Gait Disturbance5.5%2,480
12
Pain5.0%2,230
13
Multiple Sclerosis4.9%2,213
14
Condition Aggravated4.5%2,010
15
Depression4.0%1,789

These are voluntary reports and do not establish that teriflunomide caused these reactions.

Report severity

43.3%Serious19,359 reports
14.2%Hospitalizations6,336 reports
1.6%Fatal725 reports

Seriousness is determined by the reporter, not by OpenClaim.

Teriflunomide drug interactions

Other drugs that appear in adverse event reports alongside teriflunomide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dalfampridine5.8%2,579
2
Dimethyl1.4%610
3
Interferon0.9%404
4
Ocrelizumab0.9%387
5
Fingolimod0.8%365
6
Natalizumab0.7%296
7
Glatiramer-acetate0.6%289
8
Gabapentin0.4%158
9
Alemtuzumab0.3%113
10
Tizanidine-hydrochloride0.2%111
11
Peginterferon0.2%110
12
Pregabalin0.2%101
13
Ofatumumab0.2%100
14
Methylprednisolone0.2%90
15
Baclofen0.2%88

Taken alongside

1
Ergocalciferol9.7%4,341
2
Gabapentin5.8%2,592
3
Baclofen5.6%2,506
4
Acetaminophen3.5%1,575
5
Levothyroxine-sodium3.4%1,505
6
Aspirin2.8%1,272
7
Cyanocobalamin2.8%1,252
8
Ibuprofen2.7%1,189
9
Omeprazole2.6%1,166
10
Dalfampridine2.5%1,117
11
Lisinopril2.5%1,101
12
Atorvastatin-calcium2.5%1,096
13
Duloxetine-hydrochloride2.2%992
14
Amlodipine2.2%962
15
Calcium2.0%880

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports teriflunomide side effects

74.1% of teriflunomide adverse event reports involve female patients and 18.0% involve male patients. The largest age group is adult at 87%. These figures reflect who reports side effects, not underlying risk.

Sex

Female74.1%
Male18.0%
Unknown7.9%

Age group

< 20.1%
2–11<0.1%
12–17<0.1%
18–6487.4%
65+12.4%

What is teriflunomide used for

Conditions and purposes for which patients were taking teriflunomide when the adverse event was reported.

5q Minus SyndromeAccidental Exposure To ProductAlopeciaAnxiety DisorderArthralgiaArthropathyAstheniaAsthmaAtaxiaAttention Deficit/hyperactivity DisorderAutoimmune Demyelinating DiseaseAbnormal Weight GainAdverse Drug ReactionAnti-nmda AntibodyAnxiety Disorder

Showing 15 of 282 indications

Teriflunomide brand names and reporting trend

Teriflunomide is sold under the brand name Teriflunomide.

Brand names

Teriflunomide7,753

Quarterly reports (20102025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking teriflunomide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.