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Teprotumumab Side Effects

The most commonly reported side effects of teprotumumab include muscle spasms, fatigue, and tinnitus, based on 5,215 FDA adverse event reports from 2020 to 2025. 5.6% of reports found the drug to be ineffective.

Teprotumumab side effects

Percentages show how often each reaction appears relative to total reports for teprotumumab.

1
Muscle Spasms19.7%1,027
2
Fatigue13.9%723
3
Tinnitus10.6%552
4
Headache8.7%452
5
Hypoacusis8.5%442
6
Diarrhoea8.1%425
7
Nausea8.0%415
8
Blood Glucose Increased7.9%411
9
Alopecia7.7%404
10
Pain6.6%346
11
Anxiety6.4%334
12
Diplopia5.8%305
13
Drug Ineffective5.6%294
14
Weight Decreased5.5%286
15
Emotional Distress5.3%278

These are voluntary reports and do not establish that teprotumumab caused these reactions.

Report severity

39.0%Serious2,036 reports
7.6%Hospitalizations398 reports
0.6%Fatal30 reports

Seriousness is determined by the reporter, not by OpenClaim.

Teprotumumab drug interactions

Other drugs that appear in adverse event reports alongside teprotumumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Prednisone2.4%127
2
Dupilumab0.2%12
3
Denosumab0.2%11
4
Methimazole0.2%10
5
Methylprednisolone0.2%8
6
Erenumab-aooe0.1%7
7
Levothyroxine-sodium0.1%7
8
Prednisolone0.1%6
9
Sertraline-hydrochloride0.1%6
10
Rituximab0.1%6
11
Metformin<0.1%4
12
Tocilizumab<0.1%4
13
Evolocumab<0.1%4
14
Ocrelizumab<0.1%3
15
Budesonide<0.1%3

Taken alongside

1
Levothyroxine-sodium8.6%450
2
Methimazole6.3%329
3
Sodium-chloride4.8%251
4
Ergocalciferol4.8%248
5
Acetaminophen3.4%177
6
Atorvastatin-calcium2.9%151
7
Fluticasone2.5%131
8
Omeprazole2.5%130
9
Aspirin2.4%125
10
Amlodipine2.4%123
11
Sterile2.2%113
12
Albuterol2.1%112
13
Metformin2.0%106
14
Diphenhydramine2.0%105
15
Methylprednisolone2.0%105

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports teprotumumab side effects

36.3% of teprotumumab adverse event reports involve female patients and 11.2% involve male patients. The largest age group is adult at 70%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.3%
Male11.2%
Unknown52.5%

Age group

< 2<0.1%
2–110.0%
12–170.3%
18–6470.3%
65+29.3%

What is teprotumumab used for

Conditions and purposes for which patients were taking teprotumumab when the adverse event was reported.

Analgesic TherapyAutoimmune ThyroiditisAdnexa Uteri MassAsthenopiaBasedow^s DiseaseBasedow^s DiseaseBlepharitisConjunctival OedemaDiplopiaDisorder Of OrbitDiabetes MellitusDiabetic KetoacidosisDiplopiaDry EyeEndocrine Ophthalmopathy

Showing 15 of 68 indications

Teprotumumab brand names and reporting trend

Teprotumumab is sold under the brand name Tepezza.

Brand names

Tepezza301

Quarterly reports (20202025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking teprotumumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.