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Tepotinib Side Effects

The most commonly reported side effects of tepotinib include death, oedema peripheral, and diarrhoea, based on 746 FDA adverse event reports from 2004 to 2025.

Tepotinib side effects

Percentages show how often each reaction appears relative to total reports for tepotinib.

1
Death16.1%120
2
Oedema Peripheral11.9%89
3
Diarrhoea8.6%64
4
Oedema8.4%63
5
Renal Impairment8.2%61
6
Off Label Use8.0%60
7
Disease Progression7.6%57
8
Fatigue7.4%55
9
Nausea6.2%46
10
Peripheral Swelling4.6%34
11
Blood Creatinine Increased4.3%32
12
Decreased Appetite3.9%29
13
Malignant Neoplasm Progression3.2%24
14
Dyspnoea2.8%21
15
Pleural Effusion2.5%19

These are voluntary reports and do not establish that tepotinib caused these reactions.

Report severity

79.1%Serious590 reports
25.1%Hospitalizations187 reports
25.3%Fatal189 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tepotinib drug interactions

Other drugs that appear in adverse event reports alongside tepotinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Osimertinib-mesylate3.8%28
2
Carboplatin2.1%16
3
Pembrolizumab1.6%12
4
Pemetrexed1.5%11
5
Oxycodone1.1%8
6
Gefitinib0.8%6
7
Amlodipine0.8%6
8
Metoprolol0.8%6
9
Levothyroxine-sodium0.8%6
10
Capmatinib-hydrochloride0.8%6
11
Calcium-chloride0.7%5
12
Dextrose0.7%5
13
Magnesium-chloride0.7%5
14
Sodium-chloride0.7%5
15
Sodium-lactate0.7%5

Taken alongside

1
Apixaban5.0%37
2
Omeprazole4.4%33
3
Acetaminophen4.2%31
4
Furosemide3.8%28
5
Ergocalciferol3.6%27
6
Amlodipine3.5%26
7
Oxycodone3.4%25
8
Ondansetron3.1%23
9
Levothyroxine-sodium2.9%22
10
Pantoprazole-sodium2.8%21
11
Atorvastatin-calcium2.8%21
12
Metformin2.7%20
13
Metoprolol2.5%19
14
Aspirin2.5%19
15
Folic-acid2.4%18

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tepotinib side effects

52.0% of tepotinib adverse event reports involve female patients and 43.4% involve male patients. The largest age group is elderly at 85%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.0%
Male43.4%
Unknown4.6%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6414.7%
65+85.3%

What is tepotinib used for

Conditions and purposes for which patients were taking tepotinib when the adverse event was reported.

Anticoagulant TherapyAdenocarcinomaAdenosquamous Cell Lung CancerAdenosquamous Cell Lung Cancer Stage IvBronchial CarcinomaBrain NeoplasmBrain Neoplasm MalignantBronchial CarcinomaCervix CarcinomaColon CancerColorectal CancerDrug Use For Unknown IndicationDisease ProgressionGastric CancerGlioblastoma

Showing 15 of 46 indications

Tepotinib brand names and reporting trend

Tepotinib is sold under the brand name Tepmetko.

Brand names

Tepmetko260

Quarterly reports (20042025)

20042025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tepotinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.