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Temsirolimus Side Effects

The most commonly reported side effects of temsirolimus include drug dependence, overdose, and death, based on 6,242 FDA adverse event reports from 2004 to 2025.

Temsirolimus side effects

Percentages show how often each reaction appears relative to total reports for temsirolimus.

1
Drug Dependence18.7%1,168
2
Overdose10.5%655
3
Death5.8%361
4
Pain5.1%319
5
Disease Progression4.9%303
6
Drug Withdrawal Syndrome4.2%260
7
Emotional Distress3.4%214
8
Disease Progression3.2%197
9
Fatigue2.6%161
10
Nausea2.5%157
11
Vomiting2.5%154
12
Depression2.5%154
13
Diarrhoea2.3%143
14
Dyspnoea2.3%142
15
Off Label Use2.2%139

These are voluntary reports and do not establish that temsirolimus caused these reactions.

Report severity

88.7%Serious5,534 reports
39.0%Hospitalizations2,437 reports
20.8%Fatal1,300 reports

Seriousness is determined by the reporter, not by OpenClaim.

Temsirolimus drug interactions

Other drugs that appear in adverse event reports alongside temsirolimus. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Oxycodone21.1%1,317
2
Hydromorphone-hydrochloride16.9%1,057
3
Morphine-sulfate15.8%988
4
Acetaminophen15.6%976
5
Hydrocodone14.2%884
6
Tramadol-hydrochloride11.9%745
7
Bevacizumab8.9%554
8
Buprenorphine6.9%429
9
Dihydrocodeine-bitartrate6.2%390
10
Caffeine6.1%383
11
Cyclophosphamide5.0%315
12
Vincristine-sulfate5.0%315
13
Irinotecan-hydrochloride3.9%243
14
Dactinomycin3.6%226
15
Rituximab3.0%185

Taken alongside

1
Acetaminophen6.3%394
2
Ondansetron4.7%295
3
Oxycodone4.7%291
4
Furosemide3.9%244
5
Dexamethasone3.6%224
6
Amlodipine3.6%224
7
Diphenhydramine3.5%217
8
Omeprazole3.5%217
9
Lorazepam3.2%198
10
Metoprolol3.2%198
11
Morphine-sulfate3.0%189
12
Levothyroxine-sodium3.0%188
13
Prochlorperazine3.0%187
14
Aspirin3.0%186
15
Pantoprazole-sodium2.7%167

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports temsirolimus side effects

32.2% of temsirolimus adverse event reports involve female patients and 57.4% involve male patients. The largest age group is adult at 47%. These figures reflect who reports side effects, not underlying risk.

Sex

Female32.2%
Male57.4%
Unknown10.4%

Age group

< 22.8%
2–116.9%
12–172.6%
18–6447.2%
65+40.4%

What is temsirolimus used for

Conditions and purposes for which patients were taking temsirolimus when the adverse event was reported.

Abdominal NeoplasmAbdominal PainAccident At WorkAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma Of The CervixAdenocarcinoma PancreasAdenoid Cystic CarcinomaAdrenal CarcinomaAdrenal Gland CancerAdrenocortical CarcinomaAlveolar RhabdomyosarcomaAnalgesic Therapy

Showing 15 of 353 indications

Temsirolimus brand names and reporting trend

Temsirolimus is sold under the brand name Temsirolimus.

Brand names

Temsirolimus4,892

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking temsirolimus with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.