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Telbivudine Side Effects

The most commonly reported side effects of telbivudine include drug resistance, pathogen resistance, and blood creatine phosphokinase increased, based on 403 FDA adverse event reports from 2007 to 2025. 8.9% of reports found the drug to be ineffective.

Telbivudine side effects

Percentages show how often each reaction appears relative to total reports for telbivudine.

1
Drug Resistance25.1%101
2
Pathogen Resistance12.2%49
3
Blood Creatine Phosphokinase Increased11.7%47
4
Drug Ineffective8.9%36
5
Viral Mutation Identified8.9%36
6
Treatment Failure8.4%34
7
Myalgia8.2%33
8
Muscular Weakness6.5%26
9
Foetal Exposure During Pregnancy5.7%23
10
Hepatic Cirrhosis4.7%19
11
Rhabdomyolysis4.0%16
12
Multiple-drug Resistance4.0%16
13
Renal Failure4.0%16
14
Hepatitis B Dna Increased4.0%16
15
Exposure During Pregnancy3.7%15

These are voluntary reports and do not establish that telbivudine caused these reactions.

Report severity

95.5%Serious385 reports
29.8%Hospitalizations120 reports
9.4%Fatal38 reports

Seriousness is determined by the reporter, not by OpenClaim.

Telbivudine drug interactions

Other drugs that appear in adverse event reports alongside telbivudine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lamivudine35.7%144
2
Adefovir-dipivoxil33.5%135
3
Tenofovir29.5%119
4
Entecavir23.8%96
5
Ropeginterferon-alfa-2b-njft2.5%10
6
Prednisolone2.5%10
7
Cyclophosphamide2.2%9
8
Sorafenib-tosylate2.0%8
9
Ritonavir2.0%8
10
Zidovudine2.0%8
11
Emtricitabine1.7%7
12
Tacrolimus1.7%7
13
Peginterferon1.5%6
14
Atazanavir-sulfate1.5%6
15
Vincristine-sulfate1.5%6

Taken alongside

1
Adefovir-dipivoxil3.0%12
2
Entecavir2.7%11
3
Tenofovir2.7%11
4
Furosemide2.2%9
5
Lamivudine2.2%9
6
Aspirin2.2%9
7
Enalapril-maleate2.0%8
8
Valsartan2.0%8
9
Metoprolol1.7%7
10
Simvastatin1.7%7
11
Omeprazole1.5%6
12
Metformin1.5%6
13
Warfarin1.5%6
14
Dexamethasone1.2%5
15
Amlodipine1.2%5

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports telbivudine side effects

21.8% of telbivudine adverse event reports involve female patients and 51.6% involve male patients. The largest age group is adult at 82%. These figures reflect who reports side effects, not underlying risk.

Sex

Female21.8%
Male51.6%
Unknown26.6%

Age group

< 27.0%
2–110.8%
12–170.8%
18–6482.4%
65+9.0%

What is telbivudine used for

Conditions and purposes for which patients were taking telbivudine when the adverse event was reported.

Antiretroviral TherapyAntiviral ProphylaxisAntiviral TreatmentAntiviral ProphylaxisChronic HepatitisChronic Hepatitis BChronic Hepatitis CChronic Hepatitis BDrug Use For Unknown IndicationFoetal Exposure During PregnancyHepatic CirrhosisHepatitisHepatitis BHepatitis B E Antigen PositiveHepatitis C

Showing 15 of 34 indications

Telbivudine brand names and reporting trend

Telbivudine is sold under the brand name Tyzeka.

Brand names

Tyzeka387

Quarterly reports (20072025)

20072010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking telbivudine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.