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Tegaserod Side Effects

The most commonly reported side effects of tegaserod include chest pain, diarrhoea, and abdominal pain, based on 3,902 FDA adverse event reports from 2004 to 2025. 5.3% of reports found the drug to be ineffective.

Tegaserod side effects

Percentages show how often each reaction appears relative to total reports for tegaserod.

1
Chest Pain11.2%438
2
Diarrhoea10.7%417
3
Abdominal Pain10.0%392
4
Dizziness9.1%357
5
Dyspnoea8.9%348
6
Nausea8.7%340
7
Constipation7.7%301
8
Headache6.1%239
9
Asthenia5.4%212
10
Vomiting5.4%209
11
Drug Ineffective5.3%205
12
Pain4.7%182
13
Fatigue4.6%178
14
Abdominal Distension4.5%177
15
Abdominal Pain Upper4.3%166

These are voluntary reports and do not establish that tegaserod caused these reactions.

Report severity

71.6%Serious2,795 reports
28.9%Hospitalizations1,128 reports
3.7%Fatal146 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tegaserod drug interactions

Other drugs that appear in adverse event reports alongside tegaserod. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ethinyl-estradiol1.6%64
2
Esomeprazole1.6%64
3
Quetiapine-fumarate1.6%62
4
Drospirenone1.3%51
5
Metoclopramide-hydrochloride1.1%42
6
Omeprazole1.1%41
7
Pantoprazole-sodium1.0%40
8
Lansoprazole1.0%38
9
Varenicline0.9%35
10
Sodium-oxybate0.9%35
11
Pregabalin0.8%33
12
Exenatide-synthetic0.7%29
13
Teriparatide0.7%28
14
Fentanyl0.7%28
15
Acetaminophen0.7%27

Taken alongside

1
Levothyroxine-sodium10.0%392
2
Acetaminophen9.8%384
3
Esomeprazole8.9%348
4
Aspirin8.6%337
5
Hydrochlorothiazide6.8%267
6
Lansoprazole6.8%266
7
Pantoprazole-sodium6.5%254
8
Atorvastatin-calcium6.0%233
9
Furosemide5.9%229
10
Metoprolol5.8%227
11
Hydrocodone5.6%220
12
Gabapentin5.6%218
13
Alprazolam5.5%216
14
Albuterol5.2%201
15
Omeprazole4.9%193

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tegaserod side effects

83.9% of tegaserod adverse event reports involve female patients and 11.7% involve male patients. The largest age group is adult at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female83.9%
Male11.7%
Unknown4.4%

Age group

< 20.1%
2–110.8%
12–171.0%
18–6471.3%
65+26.8%

What is tegaserod used for

Conditions and purposes for which patients were taking tegaserod when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal PainAbdominal Pain UpperAnaesthetic ComplicationBowel Movement IrregularityColitisColitis CollagenousColitis IschaemicColitis UlcerativeColon CancerColonic AtonyColonoscopyCongenital MegacolonConstipation

Showing 15 of 86 indications

Tegaserod brand names and reporting trend

Tegaserod is sold under the brand name Zelnorm.

Brand names

Zelnorm154

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tegaserod with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.