OpenClaim

Tedizolid Side Effects

The most commonly reported side effects of tedizolid include off label use, product use in unapproved indication, and thrombocytopenia, based on 1,044 FDA adverse event reports from 2014 to 2025. 8.7% of reports found the drug to be ineffective.

#1 Reported: Off Label UseAll side effects ↓Top Co-Medication: LinezolidDrug interactions ↓50% of Reports Are AdultDemographics ↓

Tedizolid side effects

Percentages show how often each reaction appears relative to total reports for tedizolid.

1
Off Label Use14.6%152
2
Product Use In Unapproved Indication10.1%105
3
Thrombocytopenia8.9%93
4
Drug Ineffective8.7%91
5
Nausea7.0%73
6
Anaemia5.5%57
7
Pancytopenia4.6%48
8
Diarrhoea4.3%45
9
No Adverse Event4.0%42
10
Vomiting3.9%41
11
Neuropathy Peripheral3.9%41
12
Serotonin Syndrome3.6%38
13
Drug Interaction3.4%35
14
Product Availability Issue3.2%33
15
Product Dose Omission Issue3.2%33

These are voluntary reports and do not establish that tedizolid caused these reactions.

Report severity

70.6%Serious737 reports
32.2%Hospitalizations336 reports
9.3%Fatal97 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tedizolid drug interactions

Other drugs that appear in adverse event reports alongside tedizolid. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Linezolid16.9%176
2
Amikacin-sulfate8.5%89
3
Azithromycin8.3%87
4
Imipenem6.8%71
5
Clofazimine5.8%61
6
Daptomycin5.6%58
7
Omadacycline-tosylate5.2%54
8
Doxycycline4.4%46
9
Tigecycline3.9%41
10
Meropenem3.6%38
11
Bedaquiline-fumarate3.5%37
12
Moxifloxacin-hydrochloride3.2%33
13
Clarithromycin3.0%31
14
Cilastatin-sodium2.9%30
15
Ethambutol-hydrochloride2.9%30

Taken alongside

1
Azithromycin7.4%77
2
Meropenem6.1%64
3
Clofazimine5.9%62
4
Linezolid5.7%59
5
Amikacin-sulfate5.6%58
6
Vancomycin5.1%53
7
Tigecycline4.7%49
8
Imipenem4.6%48
9
Prednisone4.5%47
10
Acetaminophen4.3%45
11
Omadacycline-tosylate3.8%40
12
Insulin3.4%36
13
Albuterol3.2%33
14
Furosemide3.1%32
15
Bisoprolol-fumarate3.1%32

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tedizolid side effects

40.7% of tedizolid adverse event reports involve female patients and 49.3% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.7%
Male49.3%
Unknown10.0%

Age group

< 20.0%
2–110.4%
12–172.7%
18–6449.6%
65+47.4%

What is tedizolid used for

Conditions and purposes for which patients were taking tedizolid when the adverse event was reported.

Abdominal AbscessAbscessAbscess BacterialAbscess LimbAntibiotic TherapyArthritis BacterialArthritis InfectiveAtypical Mycobacterial InfectionAbscess BacterialAbscess NeckAnti-infective TherapyAntibiotic ProphylaxisAntibiotic TherapyArthritis BacterialArthritis Infective

Showing 15 of 171 indications

Tedizolid brand names and reporting trend

Tedizolid is sold under the brand name Sivextro.

Brand names

Sivextro532

Quarterly reports (2014–2025)

20142016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tedizolid with another medication?

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