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Teclistamab Side Effects

The most commonly reported side effects of teclistamab include cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, and plasma cell myeloma, based on 3,157 FDA adverse event reports from 2021 to 2025. 4.2% of reports found the drug to be ineffective.

Teclistamab side effects

Percentages show how often each reaction appears relative to total reports for teclistamab.

1
Cytokine Release Syndrome23.3%737
2
Immune Effector Cell-associated Neurotoxicity Syndrome9.1%287
3
Plasma Cell Myeloma7.3%231
4
Off Label Use6.1%193
5
Pneumonia5.7%179
6
Death5.5%173
7
Pyrexia5.3%167
8
Covid-195.0%159
9
Infection5.0%159
10
Neutropenia4.3%137
11
Drug Ineffective4.2%132
12
Fatigue3.5%111
13
Sepsis2.9%90
14
Diarrhoea2.5%80
15
Thrombocytopenia2.5%78

These are voluntary reports and do not establish that teclistamab caused these reactions.

Report severity

86.6%Serious2,735 reports
32.8%Hospitalizations1,034 reports
21.6%Fatal682 reports

Seriousness is determined by the reporter, not by OpenClaim.

Teclistamab drug interactions

Other drugs that appear in adverse event reports alongside teclistamab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Daratumumab11.1%352
2
Dexamethasone7.6%241
3
Lenalidomide7.3%232
4
Bortezomib5.7%180
5
Pomalidomide4.6%144
6
Talquetamab-tgvs4.5%142
7
Cyclophosphamide4.4%139
8
Carfilzomib4.1%131
9
Thalidomide2.8%89
10
Etoposide2.2%71
11
Doxorubicin-hydrochloride2.2%70
12
Melphalan1.5%48
13
Cisplatin1.2%38
14
Isatuximab-irfc1.2%38
15
Tocilizumab0.9%28

Taken alongside

1
Acyclovir13.9%439
2
Acetaminophen6.0%188
3
Sulfamethoxazole4.7%148
4
Trimethoprim4.6%144
5
Dexamethasone4.0%127
6
Omeprazole3.4%108
7
Apixaban3.0%95
8
Aspirin2.9%91
9
Amoxicillin2.5%78
10
Pantoprazole-sodium2.4%76
11
Bisoprolol-fumarate2.1%65
12
Atovaquone2.0%62
13
Filgrastim1.9%61
14
Tamsulosin-hydrochloride1.9%60
15
Potassium-chloride1.9%59

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports teclistamab side effects

30.4% of teclistamab adverse event reports involve female patients and 36.4% involve male patients. The largest age group is elderly at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female30.4%
Male36.4%
Unknown33.3%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6435.7%
65+64.3%

What is teclistamab used for

Conditions and purposes for which patients were taking teclistamab when the adverse event was reported.

AmyloidosisAutoimmune DisorderAutologous Haematopoietic Stem Cell TransplantBone CancerBreast CancerCardiac AmyloidosisCryoglobulinaemiaDisease ProgressionFollicular LymphomaGastrointestinal CarcinomaImmune System DisorderImmune Tolerance InductionLeukaemiaLight Chain DiseaseLupus Nephritis

Showing 15 of 37 indications

Teclistamab brand names and reporting trend

Teclistamab is sold under the brand name Tecvayli.

Brand names

Tecvayli2,197

Quarterly reports (20212025)

2021202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking teclistamab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.