OpenClaim

Tebentafusp Side Effects

The most commonly reported side effects of tebentafusp include cytokine release syndrome, pyrexia, and hypotension, based on 483 FDA adverse event reports from 2018 to 2025.

Tebentafusp side effects

Percentages show how often each reaction appears relative to total reports for tebentafusp.

1
Cytokine Release Syndrome20.7%100
2
Pyrexia18.2%88
3
Hypotension12.4%60
4
Disease Progression12.4%60
5
Rash12.0%58
6
Malignant Neoplasm Progression11.2%54
7
Chills10.6%51
8
Product Dose Omission Issue8.5%41
9
Pruritus7.7%37
10
Nausea7.5%36
11
Vomiting6.6%32
12
Death5.4%26
13
Fatigue4.6%22
14
Tachycardia3.5%17
15
Asthenia3.5%17

These are voluntary reports and do not establish that tebentafusp caused these reactions.

Report severity

76.0%Serious367 reports
34.8%Hospitalizations168 reports
18.0%Fatal87 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tebentafusp drug interactions

Other drugs that appear in adverse event reports alongside tebentafusp. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Nivolumab2.3%11
2
Pembrolizumab1.9%9
3
Ipilimumab1.7%8
4
Melphalan1.0%5
5
Dacarbazine0.8%4
6
Durvalumab0.6%3
7
Acetaminophen0.6%3
8
Prednisolone0.6%3
9
Tocilizumab0.6%3
10
Albumin-human0.4%2
11
Relatlimab-rmbw0.4%2
12
Aprepitant0.4%2
13
Bevacizumab0.2%1
14
Risankizumab-rzaa0.2%1
15
Fosaprepitant-dimeglumine0.2%1

Taken alongside

1
Levothyroxine-sodium3.9%19
2
Omeprazole3.9%19
3
Acetaminophen2.9%14
4
Atorvastatin-calcium2.5%12
5
Pantoprazole-sodium2.3%11
6
Ondansetron2.3%11
7
Amlodipine2.1%10
8
Metformin2.1%10
9
Aspirin2.1%10
10
Lisinopril1.9%9
11
Hydrocortisone1.9%9
12
Gabapentin1.7%8
13
Metoprolol1.7%8
14
Mirtazapine1.7%8
15
Ergocalciferol1.7%8

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tebentafusp side effects

27.3% of tebentafusp adverse event reports involve female patients and 26.1% involve male patients. The largest age group is elderly at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female27.3%
Male26.1%
Unknown46.6%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6437.5%
65+62.5%

What is tebentafusp used for

Conditions and purposes for which patients were taking tebentafusp when the adverse event was reported.

Choroid MelanomaCiliary Body MelanomaCytokine Release SyndromeMalignant MelanomaMalignant MelanomaMalignant Melanoma Stage IvMalignant Neoplasm Of ChoroidMetastases To LiverMetastases To MeningesMetastatic Malignant MelanomaMetastatic NeoplasmMetastatic Ocular MelanomaMyositisNauseaNeoplasm Malignant

Showing 15 of 18 indications

Tebentafusp brand names and reporting trend

Tebentafusp is sold under the brand name Kimmtrak.

Brand names

Kimmtrak187

Quarterly reports (20182025)

202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tebentafusp with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.