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Tazobactam Side Effects

The most commonly reported side effects of tazobactam include acute kidney injury, off label use, and pyrexia, based on 20,004 FDA adverse event reports from 2004 to 2025. 7.8% of reports found the drug to be ineffective.

Tazobactam side effects

Percentages show how often each reaction appears relative to total reports for tazobactam.

1
Drug Ineffective7.8%1,569
2
Acute Kidney Injury6.6%1,328
3
Off Label Use6.6%1,328
4
Pyrexia5.9%1,176
5
Pneumonia4.1%825
6
Diarrhoea3.5%697
7
Sepsis3.3%669
8
Dyspnoea2.9%588
9
Thrombocytopenia2.7%545
10
Product Use In Unapproved Indication2.6%524
11
Septic Shock2.6%519
12
Hypotension2.6%513
13
Condition Aggravated2.5%510
14
Febrile Neutropenia2.5%500
15
Rash2.4%485

These are voluntary reports and do not establish that tazobactam caused these reactions.

Report severity

93.1%Serious18,625 reports
55.8%Hospitalizations11,163 reports
22.6%Fatal4,512 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tazobactam drug interactions

Other drugs that appear in adverse event reports alongside tazobactam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Piperacillin41.5%8,296
2
Vancomycin13.7%2,738
3
Meropenem5.0%995
4
Ceftolozane-sulfate4.4%879
5
Ciprofloxacin3.9%783
6
Ceftriaxone-sodium3.6%713
7
Linezolid3.5%695
8
Methylprednisolone3.4%679
9
Dexamethasone3.4%674
10
Prednisone3.2%643
11
Cyclophosphamide3.0%594
12
Cytarabine2.9%573
13
Levofloxacin2.9%571
14
Metronidazole2.7%545
15
Amphotericin-b2.7%543

Taken alongside

1
Piperacillin52.9%10,573
2
Vancomycin17.5%3,503
3
Acetaminophen16.5%3,292
4
Furosemide11.9%2,390
5
Pantoprazole-sodium9.5%1,893
6
Ondansetron9.1%1,815
7
Insulin7.3%1,458
8
Aspirin7.2%1,447
9
Meropenem7.0%1,400
10
Dexamethasone6.7%1,347
11
Fluconazole6.6%1,325
12
Enoxaparin-sodium6.6%1,314
13
Prednisone6.5%1,306
14
Acyclovir6.5%1,305
15
Omeprazole6.5%1,291

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tazobactam side effects

38.0% of tazobactam adverse event reports involve female patients and 52.9% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.0%
Male52.9%
Unknown9.2%

Age group

< 21.9%
2–113.4%
12–172.8%
18–6450.6%
65+41.2%

What is tazobactam used for

Conditions and purposes for which patients were taking tazobactam when the adverse event was reported.

Abdominal AbscessAbdominal Cavity DrainageAbdominal DistensionAbdominal InfectionAbdominal InjuryAbdominal MassAbdominal PainAbdominal Pain UpperAbdominal RigidityAbdominal SepsisAbdominal TendernessAbdominal Wall AbscessAbdominal Wall InfectionAbscessAbscess Bacterial

Showing 15 of 1,301 indications

Tazobactam brand names and reporting trend

Tazobactam is sold under the brand name Zosyn In Plastic Container.

Brand names

Zosyn In Plastic Container406

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tazobactam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.