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Tazarotene Side Effects

The most commonly reported side effects of tazarotene include off label use, skin exfoliation, and erythema, based on 1,546 FDA adverse event reports from 2004 to 2025. 7.6% of reports found the drug to be ineffective.

Tazarotene side effects

Percentages show how often each reaction appears relative to total reports for tazarotene.

1
Drug Ineffective7.6%117
2
Off Label Use6.5%100
3
Skin Exfoliation5.8%89
4
Erythema5.7%88
5
Psoriasis5.1%79
6
Pruritus4.7%73
7
Rash4.5%69
8
Application Site Erythema4.4%68
9
Pain4.1%64
10
Headache4.0%62
11
Application Site Pain3.9%60
12
Nausea3.1%48
13
Diarrhoea3.0%47
14
Dry Skin2.7%42
15
Fatigue2.5%38

These are voluntary reports and do not establish that tazarotene caused these reactions.

Report severity

34.2%Serious528 reports
13.7%Hospitalizations212 reports
1.4%Fatal21 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tazarotene drug interactions

Other drugs that appear in adverse event reports alongside tazarotene. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Apremilast6.5%101
2
Halobetasol-propionate5.2%80
3
Adalimumab3.9%61
4
Sodium-oxybate3.9%60
5
Secukinumab3.3%51
6
Dupilumab3.1%48
7
Clobetasol-propionate2.7%42
8
Isotretinoin2.3%36
9
Ethinyl-estradiol2.2%34
10
Drospirenone1.9%30
11
Methotrexate1.9%30
12
Dapsone1.6%25
13
Etanercept1.6%24
14
Calcipotriene1.6%24
15
Risankizumab-rzaa1.4%22

Taken alongside

1
Halobetasol-propionate9.0%139
2
Clobetasol-propionate8.7%135
3
Ergocalciferol8.0%124
4
Levothyroxine-sodium7.4%114
5
Acetaminophen7.2%112
6
Clindamycin6.5%100
7
Fluticasone6.2%96
8
Albuterol6.1%95
9
Calcipotriene5.8%90
10
Gabapentin5.8%90
11
Betamethasone5.3%82
12
Aspirin4.9%75
13
Ibuprofen4.7%73
14
Doxycycline4.5%70
15
Prednisone4.2%65

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tazarotene side effects

60.5% of tazarotene adverse event reports involve female patients and 28.9% involve male patients. The largest age group is adult at 74%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.5%
Male28.9%
Unknown10.5%

Age group

< 20.3%
2–110.9%
12–1711.1%
18–6473.6%
65+14.0%

What is tazarotene used for

Conditions and purposes for which patients were taking tazarotene when the adverse event was reported.

AcneAcne CysticAcrochordonActinic KeratosisAlopecia AreataAnogenital WartsArthralgiaArthritisArthropod BiteAcneAcne CysticBasal Cell Naevus SyndromeBenign Familial PemphigusCancer SurgeryChronic Obstructive Pulmonary Disease

Showing 15 of 111 indications

Tazarotene brand names and reporting trend

Tazarotene is sold under the brand name Halobetasol Propionate And Tazarotene.

Brand names

Halobetasol Propionate And Tazarotene357

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tazarotene with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.