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Taurolidine Side Effects

The most commonly reported side effects of taurolidine include vascular device infection, vomiting, and abdominal pain, based on 161 FDA adverse event reports from 2009 to 2025.

Taurolidine side effects

Percentages show how often each reaction appears relative to total reports for taurolidine.

1
Vascular Device Infection9.9%16
2
Vomiting8.7%14
3
Abdominal Pain8.1%13
4
Acute Kidney Injury6.8%11
5
Diarrhoea6.8%11
6
Pneumonia6.2%10
7
Colitis5.6%9
8
Colitis Ischaemic5.6%9
9
Neutropenic Sepsis5.6%9
10
Anaemia5.0%8
11
Rash5.0%8
12
Immune Effector Cell-associated Neurotoxicity Syndrome5.0%8
13
Neutropenia4.3%7
14
Off Label Use4.3%7
15
Febrile Neutropenia4.3%7

These are voluntary reports and do not establish that taurolidine caused these reactions.

Report severity

93.8%Serious151 reports
65.2%Hospitalizations105 reports
10.6%Fatal17 reports

Seriousness is determined by the reporter, not by OpenClaim.

Taurolidine drug interactions

Other drugs that appear in adverse event reports alongside taurolidine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Teduglutide57.8%93
2
Cyclophosphamide9.3%15
3
Fludarabine-phosphate6.8%11
4
Pembrolizumab6.8%11
5
Trastuzumab6.2%10
6
Pertuzumab6.2%10
7
Aldesleukin6.2%10
8
Docetaxel5.6%9
9
Doxycycline5.0%8
10
Sodium-chloride4.3%7
11
Carboplatin4.3%7
12
Pemetrexed4.3%7
13
Letrozole3.7%6
14
Dextrose3.7%6
15
Nivolumab3.7%6

Taken alongside

1
Cholecalciferol39.8%64
2
Acetaminophen34.8%56
3
Loperamide-hydrochloride28.0%45
4
Potassium-chloride25.5%41
5
Ondansetron23.6%38
6
Metronidazole21.7%35
7
Sodium-chloride21.7%35
8
Pantoprazole-sodium21.7%35
9
Omeprazole19.3%31
10
Morphine-sulfate18.6%30
11
Ciprofloxacin18.6%30
12
Magnesium-acetate-tetrahydrate18.6%30
13
Sodium-bicarbonate17.4%28
14
Enoxaparin-sodium16.8%27
15
Fluconazole16.8%27

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports taurolidine side effects

64.0% of taurolidine adverse event reports involve female patients and 29.8% involve male patients. The largest age group is adult at 49%. These figures reflect who reports side effects, not underlying risk.

Sex

Female64.0%
Male29.8%
Unknown6.2%

Age group

< 21.4%
2–119.5%
12–172.7%
18–6449.3%
65+37.2%

What is taurolidine used for

Conditions and purposes for which patients were taking taurolidine when the adverse event was reported.

Amyotrophic Lateral SclerosisAntibiotic ProphylaxisAntibiotic TherapyBenign Prostatic HyperplasiaChronic Hepatitis CCatheter ManagementCatheter Site InfectionCentral Venous Catheter RemovalCentral Venous CatheterisationDevice Related InfectionDevice Related SepsisEnd Stage Renal DiseaseHypertensionHaematological InfectionHaemodialysis

Showing 15 of 32 indications

Taurolidine brand names and reporting trend

Taurolidine is sold under the brand name Defencath.

Brand names

Defencath180

Quarterly reports (20092025)

200920242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking taurolidine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.