OpenClaim

Taliglucerase Side Effects

The most commonly reported side effects of taliglucerase include fatigue, off label use, and arthralgia, based on 556 FDA adverse event reports from 2011 to 2025.

Taliglucerase side effects

Percentages show how often each reaction appears relative to total reports for taliglucerase.

1
Fatigue12.2%68
2
Off Label Use8.6%48
3
Arthralgia8.5%47
4
Headache8.1%45
5
Malaise8.1%45
6
Pain In Extremity7.9%44
7
Pyrexia7.9%44
8
Pain7.7%43
9
Dyspnoea7.2%40
10
Inappropriate Schedule Of Product Administration6.8%38
11
Back Pain6.3%35
12
Nausea6.1%34
13
Infusion Related Reaction5.9%33
14
Cough5.4%30
15
Fall5.2%29

These are voluntary reports and do not establish that taliglucerase caused these reactions.

Report severity

70.9%Serious394 reports
21.0%Hospitalizations117 reports
9.2%Fatal51 reports

Seriousness is determined by the reporter, not by OpenClaim.

Taliglucerase drug interactions

Other drugs that appear in adverse event reports alongside taliglucerase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Imiglucerase2.7%15
2
Velaglucerase-alfa2.0%11
3
Eliglustat-tartrate1.6%9
4
Diphenhydramine1.1%6
5
Miglustat0.7%4
6
Acetaminophen0.7%4
7
Cetirizine-hydrochloride0.7%4
8
Adalimumab0.4%2
9
Etanercept0.4%2
10
Exenatide-synthetic0.4%2
11
Morphine-sulfate0.4%2
12
Panitumumab0.2%1
13
Alendronate-sodium0.2%1
14
Topiramate0.2%1
15
Ammonium0.2%1

Taken alongside

1
Diphenhydramine3.6%20
2
Acetaminophen3.4%19
3
Loratadine2.7%15
4
Ergocalciferol2.3%13
5
Omeprazole2.2%12
6
Furosemide2.0%11
7
Aspirin1.8%10
8
Calcium1.8%10
9
Pregabalin1.8%10
10
Folic-acid1.4%8
11
Clonazepam1.4%8
12
Ibuprofen1.4%8
13
Spironolactone1.4%8
14
Hydrocortisone1.3%7
15
Levothyroxine-sodium1.3%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports taliglucerase side effects

53.2% of taliglucerase adverse event reports involve female patients and 39.4% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.2%
Male39.4%
Unknown7.4%

Age group

< 20.2%
2–118.2%
12–176.5%
18–6461.3%
65+23.7%

What is taliglucerase used for

Conditions and purposes for which patients were taking taliglucerase when the adverse event was reported.

ContraceptionDiabetes MellitusDisease ProgressionDiabetes MellitusEnzyme SupplementationFatigueGaucher's DiseaseGaucher^s DiseaseGaucher^s Disease Type IGaucher^s Disease Type IiiGaucher^s DiseaseGaucher^s Disease Type IGaucher^s Disease Type IiiHypertensionHepatosplenomegaly

Showing 15 of 27 indications

Taliglucerase brand names and reporting trend

Taliglucerase is sold under the brand name Elelyso.

Brand names

Elelyso219

Quarterly reports (20112025)

20112016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking taliglucerase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.