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Taletrectinib Side Effects

The most commonly reported side effects of taletrectinib include diarrhoea, vomiting, and nausea, based on 27 FDA adverse event reports from 2025 to 2025.

Taletrectinib side effects

Percentages show how often each reaction appears relative to total reports for taletrectinib.

1
Diarrhoea25.9%7
2
Vomiting22.2%6
3
Nausea14.8%4
4
Dysphagia11.1%3
5
Muscular Weakness11.1%3
6
Pyrexia7.4%2
7
Disease Progression7.4%2
8
Dyspnoea7.4%2
9
Gait Disturbance7.4%2
10
Intentional Dose Omission7.4%2
11
Incorrect Dose Administered7.4%2
12
Fatigue7.4%2
13
Dyspepsia7.4%2
14
Pruritus7.4%2
15
Renal Disorder7.4%2

These are voluntary reports and do not establish that taletrectinib caused these reactions.

Report severity

63.0%Serious17 reports
37.0%Hospitalizations10 reports
11.1%Fatal3 reports

Seriousness is determined by the reporter, not by OpenClaim.

Taletrectinib drug interactions

Other drugs that appear in adverse event reports alongside taletrectinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Taken alongside

1
Ergocalciferol18.5%5
2
Apixaban14.8%4
3
Oxycodone11.1%3
4
Calcium11.1%3
5
Ondansetron11.1%3
6
Acetaminophen7.4%2
7
Magnesium-oxide7.4%2
8
Levothyroxine-sodium7.4%2
9
Ascorbic-acid7.4%2
10
Amlodipine7.4%2
11
Albuterol7.4%2
12
Allopurinol7.4%2
13
Furosemide7.4%2
14
Megestrol-acetate3.7%1
15
Naloxone-hydrochloride3.7%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports taletrectinib side effects

51.9% of taletrectinib adverse event reports involve female patients and 33.3% involve male patients. The largest age group is adult at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.9%
Male33.3%
Unknown14.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6456.3%
65+43.8%

What is taletrectinib used for

Conditions and purposes for which patients were taking taletrectinib when the adverse event was reported.

Brain NeoplasmBreast Cancer FemaleBreast Cancer Stage IvLung AdenocarcinomaLung Neoplasm MalignantNon-small Cell Lung CancerProduct Used For Unknown Indication

Taletrectinib brand names and reporting trend

Taletrectinib is sold under the brand name Ibtrozi.

Brand names

Ibtrozi7

Quarterly reports (20252025)

20252025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking taletrectinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.