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Talazoparib Side Effects

The most commonly reported side effects of talazoparib include anaemia, neoplasm progression, and death, based on 1,658 FDA adverse event reports from 2015 to 2025.

Talazoparib side effects

Percentages show how often each reaction appears relative to total reports for talazoparib.

1
Anaemia15.6%258
2
Neoplasm Progression10.3%171
3
Death9.8%163
4
Fatigue6.5%108
5
Thrombocytopenia5.4%89
6
Off Label Use5.4%89
7
Platelet Count Decreased4.4%73
8
Haemoglobin Decreased4.3%72
9
Febrile Neutropenia4.0%66
10
Pancytopenia3.9%65
11
Malignant Neoplasm Progression3.6%60
12
Nausea3.6%59
13
Neutropenia3.1%52
14
Asthenia3.1%51
15
Dyspnoea2.8%47

These are voluntary reports and do not establish that talazoparib caused these reactions.

Report severity

80.1%Serious1,328 reports
35.3%Hospitalizations585 reports
18.3%Fatal304 reports

Seriousness is determined by the reporter, not by OpenClaim.

Talazoparib drug interactions

Other drugs that appear in adverse event reports alongside talazoparib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Enzalutamide20.3%336
2
Avelumab3.6%60
3
Irinotecan-hydrochloride3.3%54
4
Paclitaxel2.7%44
5
Carboplatin2.5%41
6
Doxorubicin-hydrochloride2.4%39
7
Atezolizumab2.2%37
8
Temozolomide2.2%36
9
Fulvestrant1.9%31
10
Palbociclib1.7%29
11
Cyclophosphamide1.7%28
12
Olaparib1.4%23
13
Exemestane1.4%23
14
Abiraterone-acetate1.2%20
15
Apixaban1.1%19

Taken alongside

1
Acetaminophen6.0%100
2
Ondansetron5.8%96
3
Enzalutamide4.3%71
4
Atorvastatin-calcium3.7%62
5
Aspirin3.3%54
6
Denosumab3.0%50
7
Oxycodone2.8%47
8
Dexamethasone2.8%46
9
Loperamide-hydrochloride2.7%44
10
Leuprolide2.7%44
11
Omeprazole2.5%42
12
Amlodipine2.5%41
13
Metoprolol2.5%41
14
Ergocalciferol2.4%39
15
Metformin2.2%36

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports talazoparib side effects

46.7% of talazoparib adverse event reports involve female patients and 43.3% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.7%
Male43.3%
Unknown10.0%

Age group

< 20.0%
2–110.5%
12–171.7%
18–6446.0%
65+51.8%

What is talazoparib used for

Conditions and purposes for which patients were taking talazoparib when the adverse event was reported.

Acute Myeloid LeukaemiaAdenocarcinoma PancreasAdenoid Cystic CarcinomaAnaemia Vitamin B12 DeficiencyAppendix CancerAcute Myeloid LeukaemiaAdenocarcinoma PancreasAgitationAlpha-thalassaemia-intellectual Deficit SyndromeAntiandrogen TherapyBasal Cell CarcinomaBlood Bilirubin IncreasedBone CancerBrca1 Gene MutationBrca2 Gene Mutation

Showing 15 of 164 indications

Talazoparib brand names and reporting trend

Talazoparib is sold under the brand name Talzenna.

Brand names

Talzenna1,052

Quarterly reports (20152025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking talazoparib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.