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Tagraxofusp Side Effects

The most commonly reported side effects of tagraxofusp include capillary leak syndrome, pyrexia, and death, based on 504 FDA adverse event reports from 2018 to 2025. 5.6% of reports found the drug to be ineffective.

Tagraxofusp side effects

Percentages show how often each reaction appears relative to total reports for tagraxofusp.

1
Capillary Leak Syndrome24.4%123
2
Pyrexia9.3%47
3
Death7.9%40
4
Disease Progression6.9%35
5
Thrombocytopenia6.0%30
6
Off Label Use5.8%29
7
Drug Ineffective5.6%28
8
Tumour Lysis Syndrome5.2%26
9
Weight Increased5.2%26
10
Acute Kidney Injury5.0%25
11
Blood Albumin Decreased4.8%24
12
Sepsis4.4%22
13
Transaminases Increased4.4%22
14
Hypoalbuminaemia4.2%21
15
Hypotension3.8%19

These are voluntary reports and do not establish that tagraxofusp caused these reactions.

Report severity

84.3%Serious425 reports
26.6%Hospitalizations134 reports
29.8%Fatal150 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tagraxofusp drug interactions

Other drugs that appear in adverse event reports alongside tagraxofusp. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Venetoclax8.7%44
2
Azacitidine5.4%27
3
Vincristine-sulfate4.0%20
4
Cyclophosphamide3.8%19
5
Cytarabine3.2%16
6
Doxorubicin-hydrochloride3.0%15
7
Decitabine2.4%12
8
Dexamethasone2.2%11
9
Methotrexate2.0%10
10
Gemtuzumab-ozogamicin2.0%10
11
Methylprednisolone1.8%9
12
Prednisolone1.6%8
13
Etoposide1.4%7
14
Prednisone1.4%7
15
Idarubicin-hydrochloride1.0%5

Taken alongside

1
Acyclovir6.9%35
2
Acetaminophen4.4%22
3
Allopurinol4.4%22
4
Methylprednisolone3.8%19
5
Furosemide3.6%18
6
Pantoprazole-sodium3.0%15
7
Posaconazole2.8%14
8
Dexamethasone2.6%13
9
Amlodipine2.2%11
10
Albumin-human2.2%11
11
Levofloxacin2.2%11
12
Diphenhydramine2.0%10
13
Aspirin2.0%10
14
Trimethoprim2.0%10
15
Meropenem1.6%8

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tagraxofusp side effects

17.5% of tagraxofusp adverse event reports involve female patients and 58.9% involve male patients. The largest age group is elderly at 59%. These figures reflect who reports side effects, not underlying risk.

Sex

Female17.5%
Male58.9%
Unknown23.6%

Age group

< 20.0%
2–110.6%
12–174.6%
18–6435.9%
65+59.0%

What is tagraxofusp used for

Conditions and purposes for which patients were taking tagraxofusp when the adverse event was reported.

Acute Myeloid LeukaemiaAcute Myeloid Leukaemia RefractoryAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RecurrentAcute Myeloid Leukaemia RefractoryAcute Undifferentiated LeukaemiaAllogenic Stem Cell TransplantationBlastic Plasmacytoid Dendritic Cell NeoplasiaBlastic Plasmacytoid Dendritic Cell NeoplasiaChronic Myelomonocytic LeukaemiaHaematological MalignancyLeukaemiaLeukaemia Recurrent

Showing 15 of 29 indications

Tagraxofusp brand names and reporting trend

Tagraxofusp is sold under the brand name Elzonris.

Brand names

Elzonris105

Quarterly reports (20182025)

20182020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tagraxofusp with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.