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Tafasitamab Side Effects

The most commonly reported side effects of tafasitamab include disease progression, off label use, and diffuse large b-cell lymphoma, based on 2,391 FDA adverse event reports from 2020 to 2025. 4.6% of reports found the drug to be ineffective.

Tafasitamab side effects

Percentages show how often each reaction appears relative to total reports for tafasitamab.

1
Disease Progression30.3%724
2
Off Label Use16.8%402
3
Diffuse Large B-cell Lymphoma16.3%389
4
Death9.0%215
5
Lymphoma9.0%215
6
Neutropenia6.4%152
7
Covid-195.4%128
8
Drug Ineffective4.6%111
9
Pneumonia4.1%98
10
General Physical Health Deterioration3.8%91
11
Malignant Neoplasm Progression3.7%88
12
Thrombocytopenia3.5%84
13
Febrile Neutropenia3.3%78
14
Diarrhoea2.9%69
15
Infection2.8%67

These are voluntary reports and do not establish that tafasitamab caused these reactions.

Report severity

89.8%Serious2,147 reports
24.9%Hospitalizations596 reports
26.1%Fatal624 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tafasitamab drug interactions

Other drugs that appear in adverse event reports alongside tafasitamab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide68.4%1,636
2
Rituximab38.1%911
3
Cyclophosphamide24.8%594
4
Vincristine-sulfate23.9%572
5
Doxorubicin-hydrochloride21.7%518
6
Prednisone17.2%412
7
Bendamustine-hydrochloride16.6%398
8
Polatuzumab-vedotin-piiq15.3%365
9
Dexamethasone10.9%261
10
Gemcitabine9.5%227
11
Cytarabine9.5%227
12
Oxaliplatin8.6%205
13
Prednisolone7.4%176
14
Etoposide7.2%171
15
Cisplatin6.1%147

Taken alongside

1
Acyclovir11.5%275
2
Lenalidomide8.4%201
3
Trimethoprim6.6%159
4
Sulfamethoxazole6.1%146
5
Allopurinol5.8%138
6
Acetaminophen5.6%134
7
Pantoprazole-sodium5.3%126
8
Aspirin5.0%119
9
Enoxaparin-sodium3.4%81
10
Omeprazole3.2%76
11
Furosemide3.0%71
12
Bisoprolol-fumarate2.7%64
13
Ondansetron2.6%62
14
Prednisone2.3%54
15
Levothyroxine-sodium2.3%54

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tafasitamab side effects

26.5% of tafasitamab adverse event reports involve female patients and 28.7% involve male patients. The largest age group is elderly at 71%. These figures reflect who reports side effects, not underlying risk.

Sex

Female26.5%
Male28.7%
Unknown44.8%

Age group

< 20.2%
2–110.0%
12–170.0%
18–6428.8%
65+71.0%

What is tafasitamab used for

Conditions and purposes for which patients were taking tafasitamab when the adverse event was reported.

Acute Lymphocytic LeukaemiaAcute Promyelocytic LeukaemiaB-cell LymphomaB-cell LymphomaB-cell Lymphoma RecurrentB-cell Lymphoma RefractoryB-cell Lymphoma Stage IvB-cell Type Acute LeukaemiaCovid-19Central Nervous System LymphomaChemotherapyChronic Lymphocytic LeukaemiaChronic Lymphocytic Leukaemia TransformationCutaneous LymphomaDiffuse Large B-cell Lymphoma

Showing 15 of 51 indications

Tafasitamab brand names and reporting trend

Tafasitamab is sold under the brand name Monjuvi.

Brand names

Monjuvi2,901

Quarterly reports (20202025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tafasitamab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.