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Tafamidis Side Effects

The most commonly reported side effects of tafamidis include death, off label use, and cardiac failure, based on 15,017 FDA adverse event reports from 2012 to 2025.

Tafamidis side effects

Percentages show how often each reaction appears relative to total reports for tafamidis.

1
Death26.5%3,976
2
Off Label Use6.9%1,043
3
Cardiac Failure6.9%1,042
4
Dyspnoea6.1%914
5
Fatigue4.5%681
6
Fall3.6%544
7
Atrial Fibrillation3.4%507
8
Dizziness2.9%440
9
Asthenia2.8%426
10
Malaise2.8%416
11
Condition Aggravated2.6%387
12
Weight Decreased2.5%375
13
Cardiac Failure Congestive2.4%354
14
Disease Progression2.3%345
15
Hypoacusis2.3%338

These are voluntary reports and do not establish that tafamidis caused these reactions.

Report severity

79.4%Serious11,919 reports
27.8%Hospitalizations4,182 reports
35.6%Fatal5,348 reports

Seriousness is determined by the reporter, not by OpenClaim.

Tafamidis drug interactions

Other drugs that appear in adverse event reports alongside tafamidis. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Apixaban3.5%531
2
Furosemide1.3%202
3
Vutrisiran-sodium0.9%142
4
Amiodarone-hydrochloride0.9%133
5
Patisiran-sodium0.8%122
6
Spironolactone0.7%104
7
Inotersen-sodium0.7%103
8
Rosuvastatin0.5%79
9
Atorvastatin-calcium0.5%77
10
Metoprolol0.4%67
11
Metformin0.4%54
12
Torsemide0.3%50
13
Rivaroxaban0.3%50
14
Valsartan0.3%50
15
Gabapentin0.3%46

Taken alongside

1
Furosemide9.5%1,423
2
Apixaban7.4%1,111
3
Spironolactone5.6%841
4
Atorvastatin-calcium4.9%734
5
Metoprolol3.7%563
6
Torsemide3.4%511
7
Aspirin3.1%465
8
Levothyroxine-sodium2.8%414
9
Amiodarone-hydrochloride2.8%413
10
Rosuvastatin2.6%391
11
Allopurinol2.3%347
12
Pantoprazole-sodium2.3%341
13
Tamsulosin-hydrochloride2.2%333
14
Rivaroxaban2.2%325
15
Ergocalciferol2.1%322

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports tafamidis side effects

17.3% of tafamidis adverse event reports involve female patients and 71.7% involve male patients. The largest age group is elderly at 95%. These figures reflect who reports side effects, not underlying risk.

Sex

Female17.3%
Male71.7%
Unknown11.0%

Age group

< 2<0.1%
2–11<0.1%
12–170.0%
18–644.7%
65+95.3%

What is tafamidis used for

Conditions and purposes for which patients were taking tafamidis when the adverse event was reported.

Alpha-thalassaemia-intellectual Deficit SyndromeAmyloidosisAmyloidosis SenileAnticoagulant TherapyArteriosclerosisAstheniaAtrial FibrillationAtrioventricular BlockAcquired Attr AmyloidosisAcute Left Ventricular FailureAdenomatous Polyposis ColiAmyloidosisAmyloidosis SenileAnaemiaAneurysm

Showing 15 of 257 indications

Tafamidis brand names and reporting trend

Tafamidis is sold under brand names including Vyndamax, Vyndaqel.

Brand names

Vyndamax1,596
Vyndaqel571

Quarterly reports (20122025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking tafamidis with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.